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Background: ClpP1P2 is a novel protease complex essential for viability of Mycobacterium tuberculosis. Results: Cleavage preferences of ClpP1P2 were defined, which allowed us to design potent substrate-based boronate inhibitors showing anti-mycobacterial activity. Conclusion: Excellent new fluorogenic peptide substrates of ClpP1P2 were obtained, and novel enzyme properties were identified. Significance: Selective inhibition of ClpP1P2 activity is a promising approach for drug development.

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Although high levels of self-reported fatigue did not show any effects on cognitive function, other factors in the environment may contribute to delayed, missed, or inappropriate care. Further research is indicated.