Background and objectives Because of its beneficial off‐target effects against non‐mycobacterial infectious diseases, bacillus Calmette–Guérin (BCG) vaccination might be an accessible early intervention to boost protection against novel pathogens. Multiple epidemiological studies and randomised controlled trials (RCTs) are investigating the protective effect of BCG against coronavirus disease 2019 (COVID‐19). Using samples from participants in a placebo‐controlled RCT aiming to determine whether BCG vaccination reduces the incidence and severity of COVID‐19, we investigated the immunomodulatory effects of BCG on in vitro immune responses to SARS‐CoV‐2. Methods This study used peripheral blood taken from participants in the multicentre RCT and BCG vaccination to reduce the impact of COVID‐19 on healthcare workers (BRACE trial). The whole blood taken from BRACE trial participants was stimulated with γ‐irradiated SARS‐CoV‐2‐infected or mock‐infected Vero cell supernatant. Cytokine responses were measured by multiplex cytokine analysis, and single‐cell immunophenotyping was made by flow cytometry. Results BCG vaccination, but not placebo vaccination, reduced SARS‐CoV‐2‐induced secretion of cytokines known to be associated with severe COVID‐19, including IL‐6, TNF‐α and IL‐10. In addition, BCG vaccination promoted an effector memory phenotype in both CD4+ and CD8+ T cells, and an activation of eosinophils in response to SARS‐CoV‐2. Conclusions The immunomodulatory signature of BCG’s off‐target effects on SARS‐CoV‐2 is consistent with a protective immune response against severe COVID‐19.
Objectives In acoustic voice analysis, reproducible methods of sample selection are not defined, impeding research study generalizability and clinical assessment of treatment efficacy. Because perturbation results differ along a single signal, this study sought to establish objective methods of sample selection using a moving window to determine the most stable regions of phonation. Methods Voice signals obtained from 21 patients affected by laryngeal conditions associated with Parkinson’s disease were analyzed to study jitter, shimmer, signal-to-noise ratio (SNR), and correlation dimension (D2) parameters when various sample selection procedures are used. Objectively selected voice samples were chosen based upon 5%, 10%, and 20% variance from a signal’s minimum perturbation value. The stability of these samples, defined by standard deviations of the acoustic measurements, was compared to the stability of unselected samples and subjectively selected samples. Results A significant decrease in standard deviation values of acoustic parameters was found when comparing the objectively selected samples (particularly those selected with 5% and 10% variance) to the subjectively selected and unselected samples. Conclusions These results suggest that the development of an objective sample selection method may have significant effects on the stability and reliability of acoustic voice measurements.
the terms of the Creative Commons-Attribution-Noncommercial-Share Alike License 2.5 Canada (http://creativecommons.org/licenses/by-nc-sa/2.5/ca/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly attributed, not used for commercial purposes, and, if transformed, the resulting work is redistributed under the same or similar license to this one. AbstractObjective -To determine the frequency of graduate students' Google Scholar usage, and the contributing factors to their adoption. The researchers also aimed to examine whether the Technology Acceptance Model (TAM) is applicable to graduate students' acceptance of Google Scholar.Design -Web-based survey questionnaire.Setting -The survey was conducted over the internet through email invitations.
A Review of: Gross, M. & Latham, D. (2013). Addressing below proficient information literacy skills: Evaluating the efficacy of an evidence-based educational intervention. Library & Information Science Research, 35(3), 181-190. Objective – To evaluate the impact of an educational intervention workshop on students’ information literacy (IL) skills and self-perception of their own IL knowledge. Design – Quasi-experimental design with control groups and semi-structured interviews. Setting – Two community colleges in the United States of America, one in a rural setting and one in an urban setting. Subjects – Ninety-two students enrolled in an entry-level English course, who scored below proficiency (65%) on the Information Literacy Test (ILT). Methods – One hundred students from each college took the pre-session ILT and an IL self-assessment survey at the beginning of the Spring 2011 semester. The ILT used was developed and validated by James Madison University (Wise, Cameron, Yang, & Davis, n.d.) and measures understanding of all the Association of College and Research Libraries (ACRL) Information Literacy Competency Standards (ACRL, 2000, pp. 2-3) except Standard 4. For motivation, students each received $20 for their efforts and were told those who scored in the top 15% would enter a draw to win one of two additional prizes of $50. Those who scored below the ILT proficiency level of 65% were invited to participate in the quasi-experiment. Forty-nine participants were assigned to the workshop group and 43 to the control group. The two groups were comparable in demographic characteristics, prior IL learning, and ILT scores. Those in the workshop group were ask to attend one of five workshops designed around the Analyze, Search, Evaluate (ASE) process model for IL interventions (Gross, Armstrong, & Latham, 2012). The workshops were offered on both campuses and taught by the same instruction librarian. The workshop participants completed questionnaires, which included a second ILT, self-assessment, and ASE-based questions, before and after the IL workshops. Each workshop participant received $30. The control group participants took the same post-session questionnaire after the workshops were completed and received $20. The same $50 incentive was offered to both groups. Two weeks after the workshops, semi-structured individual interviews were conducted with 30 participants to analyze their learning experiences. Results – Participants’ self-assessment of IL skills showed significant downgrading after they took the ILT for the first time. This downward calibration held true for both the control (t (41) = 4.077, p < 0.004) and the workshop (t (45) = 4.149, p < 0.000) groups. Subsequent self-ratings from the control group showed this downward recalibration of self-assessment was sustained over time. For participants in the workshop group, their average self-rating of IL ability rose from a pre-ASE workshop rating of 2.79 out of a maximum score of 5, to a post-workshop rating of 3.83. However, the same participants’ post-workshop ILT scores did not show any significant improvement. Attending the ASE workshop did not help participants to achieve the “proficient” IL skill level (an ILT score of 65% or higher). Nonetheless, the workshop group’s performance on the ASE focused questions, also administered pre- and post-session, indicated that participants did gain some IL skills during the workshop. On the ASE questions, which had a maximum score of 25 points, the workshop group’s average score increased from 10.62, pre-session to 13.40, post-session, while the control group had an average score of 10.91 pre-session and 10.77 post-session. In the follow-up interviews, most participants reviewed the workshop positively and felt that their peers would benefit from attending. However, the skills participants reported learning primarily focused on the Search stage of the ASE model, such as exact phrase, truncation, and the advanced search options in Google. Conclusion – This quasi-experiment examined the impact of a one-hour ASE model-based workshop on first-year English students with below-proficiency IL skill levels. Self-assessment ratings indicated that workshop attendance increased students’ confidence in their skill level, although this upward recalibration of self-view significantly overestimated participants’ actual skill gain. Pre- and post-test questionnaires indicated that, while students did gain some new IL knowledge, attending the workshop was insufficient to improve their IL skill to the proficient level.
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