“Borderline Personality Disorder” (BPD) is associated with heightened risk for cardiovascular disease and other stress-associated somatic consequences, which is poorly understood in terms of causal mechanisms, such as childhood trauma. Here, we tested the hypothesis suggesting that BPD reflects a fast “Pace-of-Life-Syndrome” (PoLS). Ninety-five women (44 diagnosed with BPD) were recruited to examine psychological correlates of PoLS, including life history features, personality dimensions, aggressiveness, chronic stress, borderline symptom severity, childhood trauma, and allostatic load (AL). In line with expectations, BPD patients had significantly higher scores suggestive of a fast PoLS than controls, they were more aggressive, more burdened with chronic stress and were exposed to more severe childhood adversity. Childhood trauma predicted PoLS, which in turn predicted AL. The present study thus provides direct evidence of psychological and somatic traits associated with the fast end of the PoLS spectrum in females with BPD. Findings are discussed with regard to clinical implications.
Introduction. Borderline Personality Disorder (BPD) is characterised, among other features, by increased impulsivity and aggression, both directed toward the self and others. These clinical signs most likely arise from complex gene-environment interactions. In our study, we sought to elucidate the role of prenatal testosterone exposure in female patients with BPD. Materials and Methods. In a sample of 42 patients and 50 controls matched for age and biological sex, we measured the ratio of the second to the fourth digit of both hands (2D:4D ratio), which is established as a reliable correlate of prenatal testosterone levels in the foetus. In addition, we used several self-rating scales to determine personality dimensions, impulsivity, aggressiveness and risk-taking behaviour.Results. No differences between the groups emerged with regard to 2D:4D ratio of both hands. In addition, there were almost no correlations between psychological measures and the 2D:4D ratio in the entire sample. Conclusions. Contrary to predictions, female patients with BPD did not differ from controls in 2D:4D ratio bimanually, suggesting no abnormal intrauterine (prenatal) exposure to testosterone in this clinical group. As expected, differences between patients and controls in personality traits, impulsivity, aggressiveness and risk-taking were highly significant and in concordance with the existing body of knowledge. Since BPD features are highly heterogeneous, it could be interesting to study subgroups of BPD patients, rather than the broader phenotype according to DSM-5 criteria.
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