The use of agricultural technologies has facilitated gains from agricultural commercialisation for smallholder farmers in Africa. Practices that involve these technologies play an important role in tackling poverty and food insecurity in Sub-Saharan Africa. Hence, the link between agricultural technology practices, food security and nutrition is important, and has relevant implications for policymaking. Using new panel data for oil palm producers in Ghana from the Agricultural Policy Research in Africa (APRA) consortium, this paper sheds light on the relationship between the use of agricultural practices, food security and nutrition outcomes, focusing especially on the mediating role of women empowerment.