Mild cognitive impairment (MCI) has been considered as a transition phase to Alzheimer's disease (AD), and the diagnosis of MCI may help patients to carry out appropriate treatments to delay or even prevent AD. Recent advanced network analysis techniques utilizing resting-state functional Magnetic Resonance Imaging (rs-fMRI) has been widely used to get more comprehensive understanding of neurological disorders at a whole-brain connectivity level. However, how to explore effective brain functional connectivity from fMRI data is still a challenge especially when the ultimate goal is to train classifiers for discriminating patients effectively. In our research, we studied the functional connectivity of the whole brain by calculating Pearson's correlation coefficients based on rs-fMRI data, and proposed a set of novel features by applying Two Sample T-Test on the correlation coefficients matrix to identify the most discriminative correlation coefficients. We trained a L2-regularized Logistic Regression classifier based on the five novel features for the first time and evaluated the classification performance via leave-one-out cross validation. We also iterated 10-fold cross validation ten times in order to evaluate the statistical significance of our method. The experiment result demonstrates that classification accuracy and the area under receiver operating characteristic (ROC) curve in our method are 87.5% and 0.929 respectively, and the statistical results prove that our method is statistically significant better than other three algorithms, which means our method could be meaningful to assist physicians efficiently in "real-world" diagnostic situations.
Background: Currently, Parkinson’s disease (PD) diagnosis is mainly based on medical history and physical examination, and there is no objective and consistent basis. By the time of diagnosis, the disease would have progressed to the middle and late stages. Pilot studies have shown that a unique smell was present in the skin sebum of PD patients. This increases the possibility of a noninvasive diagnosis of PD using an odor profile. Methods: Fast gas chromatography (GC) combined with a surface acoustic wave sensor with embedded machine learning (ML) algorithms was proposed to establish an artificial intelligent olfactory (AIO) system for the diagnosis of Parkinson’s through smell. Sebum samples of 43 PD patients and 44 healthy controls (HCs) from Fourth Affiliated Hospital of Zhejiang University School of Medicine, China, were smelled by the AIO system. Univariate and multivariate methods were used to identify the significant volatile organic compound (VOC) features in the chromatograms. ML algorithms, including support vector machine, random forest (RF), k nearest neighbor (KNN), AdaBoost (AB), and Naive Bayes (NB), were used to distinguish PD patients from HC based on the VOC peaks in the chromatograms of sebum samples. Results: VOC peaks with average retention times of 5.7, 6.0, and 10.6 s, respectively, corresponding to octanal, hexyl acetate, and perillic aldehyde, were significantly different in PD and HC. The accuracy of the classification based on the significant features was 70.8%. Based on the odor profile, the classification had the highest accuracy and F1 of the five models with 0.855 from NB and 0.846 from AB, respectively, in the process of model establishing. The highest specificity and sensitivity of the five classifiers were 91.6% from NB and 91.7% from RF and KNN, respectively, in the evaluating set. Conclusions: The proposed AIO system can be used to diagnose PD through the odor profile of sebum. Using the AIO system is helpful for the screening and diagnosis of PD and is conducive to further tracking and frequent monitoring of the PD treatment process.
Lung cancer has been studied for decades because of its high morbidity and high mortality. Traditional methods involving bronchoscopy and needle biopsy are invasive and expensive, which makes patients suffer more risks and costs. Various noninvasive lung cancer markers, such as medical imaging indices, volatile organic compounds (VOCs), and exhaled breath condensates (EBCs), have been discovered for application in screening, diagnosis, and prognosis. However, the detection of markers still relies on bulky and professional instruments, which are limited to training personnel or laboratories. This seriously hinders population screening for early diagnosis of lung cancer. Advanced smartphones integrated with powerful applications can provide easy operation and real-time monitoring for healthcare, which demonstrates tremendous application scenarios in the biomedical analysis region from medical institutions or laboratories to personalized medicine. In this review, we propose an overview of lung-cancer-related noninvasive markers from exhaled breath, focusing on the novel development of smartphone-based platforms for the detection of these biomarkers. Lastly, we discuss the current limitations and potential solutions.
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