No abstract

Increasing exposure time to aerosol measles vaccine elicits immune responses that are comparable to those seen when an equivalent dose is administered by the subcutaneous route in 9-month-old infants.

Measles virus (MeV) represents one of the main causes of death among young children, particularly in developing countries. Upon infection, MeV controls both interferon induction (IFN) and the interferon signaling pathway which results in a severe host immunosuppression that can persists for up to 6 mo after infection. Despite the global biology of MeV infection is well studied, the role of the plasmacytoid dendritic cells (pDCs) during the host innate immune response after measles vaccination remains largely uncharacterized. Here we investigated the role of pDCs, the major producers of interferon in response to viral infections, in the development of adaptive immune response against MeV vaccine. We report that there is a strong correlation between pDCs population and the humoral immune response to Edmonston Zagreb (EZ) measles vaccination in 9-month-old mexican infants. Five infants were further evaluated after vaccination, showing a clear increase in pDCs at baseline, one week and 3 months after immunization. Three months postvaccination they showed increase in memory T-cells and pDCs populations, high induction of adaptive immunity and also observed a correlation between pDCs number and the humoral immune response. These findings suggest that the development and magnitude of the adaptive immune response following measles immunization is directly dependent on the number of pDCs of the innate immune response.

No abstract

No abstract

Turner syndrome is identified by the combination of a number of phenotypic findings at birth as lymphedema of hands and feet, "pterygium colli, " shield chest, congenital cardiopathy, and characteristic morphological data birth whose etiology is supported in the cytogenetic study that determines the total absence of an X chromosome, monosomy of chromosome X, (45, X), identified in 40-60% of cases. It is one of the most frequent chromosomal abnormalities. Congenital diaphragmatic hernia (CDH) is a common birth defect. 2% occur in the anterior Morgagni orifice, the etiology of the majority of the cases remains unknown, but there is growing evidence of genetic causation, the data are supported by the association with recurrent chromosomal abnormalities and the existence of multiple transmission families of CDH; however, there are not many records in association with total or partial monosomy of chromosome X, reason for this report.