Tumor cells primarily utilize aerobic glycolysis for energy production, a phenomenon known as the Warburg effect, but the involvement of Warburg effect in liver cancer cell metastasis is not well understood. In present study, our results indicate a positive correlation between glucose metabolism level and metastatic potential of hepatocellular carcinoma (HCC). We also observed that a long noncoding RNA-SOX2OT (lncRNA-SOX2OT) can not only increase the metastatic potential of HCC but also promote a pyruvate kinase M2 (PKM2)-mediated activation of glucose metabolism. Inhibition of PKM2 in HCC cells greatly compromises lncRNA-SOX2OT in promoting Warburg effect and metastasis. Furthermore, miR-122-5p was found being a direct target of lncRNA-SOX2OT in regulating PKM2 expression. Thus, our findings reveal that lncRNA-SOX2OT, a regulator of PKM2, could predispose HCC patients to metastases and may serve as a candidate for metastatic prediction and therapies in HCC patients.
As one of the most common disasters in deep mine roadway, floor heave has caused serious obstacles to mine transportation and normal production activities. The third section winch roadway in the third mining area of Qitaihe Longhu coal mine has a serious floor heave due to the large buried depths of the roadway and the semicoal rock roadway, and the maximum floor heave is 750 mm. For the problem of floor stability, this paper establishes a mechanical model to analyze the stability of roadway floor heave by analogy with the basement heave of deep foundation pit. It provides a model reference for analyzing the problem of roadway floor heave. Aiming at the problem of roadway floor heave in Longhu coal mine, the roadway model is established by using FLAC3D, and the roadway model after support is established according to the on-site support measures. Through the analysis of the distribution of roadway plastic area, stress nephogram, and displacement field simulation results, the results show that the maximum displacement of roadway roof and floor after support is reduced by 15% and 23%, but the maximum floor heave is still 770 mm, which is close to the measured floor heave of roadway. In order to solve the problem of roadway floor heave and integrate economic factors, this paper puts forward three support optimization schemes, simulates the support effect of each scheme, and finally determines that scheme 3 is the best support optimization scheme. Compared with that under the original support, the amount of floor heave is reduced by 81%, and the final amount of floor heave is 150 mm, which can meet the requirements of roadway floor deformation. The results provide a scheme and guidance for roadway support optimization.
Hepatocellular carcinoma (HCC) ranks the second most lethal tumor globally and is the fourth leading cause of cancer-related death worldwide. Unfortunately, HCC is commonly at intermediate tumor stage or advanced tumor stage, in which only some palliative treatment can be used to offer a limited overall survival. Due to the high heterogeneity of the genetic, molecular, and histological levels, HCC makes the prediction of preoperative transarterial chemoembolization (TACE) efficacy and the development of personalized regimens challenging. In this study, a new multi-modal point-of-care system is employed to predict the response of TACE in HCC by a concept of integrating multi-modal large-scale data of clinical index and computed tomography (CT) images. This multi-modal point-of-care predicting system opens new possibilities for predicting the response of TACE treatment and can help clinicians select the optimal patients with HCC who can benefit from the interventional therapy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.