The past decades were witnessing unprecedented habitat degradation across the globe. It thus is of great significance to investigate the impacts of land use change on habitat quality in the context of rapid urbanization, particularly in developing countries. However, rare studies were conducted to predict the spatiotemporal distribution of habitat quality under multiple future land use scenarios. In this paper, we established a framework by coupling the future land use simulation (FLUS) model with the Intergrated Valuation of Environmental Services and Tradeoffs (InVEST) model. We then analyzed the habitat quality change in Dongying City in 2030 under four scenarios: business as usual (BAU), fast cultivated land expansion scenario (FCLE), ecological security scenario (ES) and sustainable development scenario (SD). We found that the land use change in Dongying City, driven by urbanization and agricultural reclamation, was mainly characterized by the transfer of cultivated land, construction land and unused land; the area of unused land was significantly reduced. While the habitat quality in Dongying City showed a degradative trend from 2009 to 2017, it will be improved from 2017 to 2030 under four scenarios. The high-quality habitat will be mainly distributed in the Yellow River Estuary and coastal areas, and the areas with low-quality habitat will be concentrated in the central and southern regions. Multi-scenario analysis shows that the SD will have the highest habitat quality, while the BAU scenario will have the lowest. It is interesting that the ES scenario fails to have the highest capacity to protect habitat quality, which may be related to the excessive saline alkali land. Appropriate reclamation of the unused land is conducive to cultivated land protection and food security, but also improving the habitat quality and giving play to the versatility and multidimensional value of the agricultural landscape. This shows that the SD of comprehensive coordination of urban development, agricultural development and ecological protection is an effective way to maintain the habitat quality and biodiversity.
Total joint replacement (TJR) is widely applied as a
promising
treatment for the reconstruction of serious joint diseases but is
usually characterized by critical loss of skeletal muscle attachment
to metal joint prostheses, resulting in fibrous scar tissue formation
and subsequent motor dysfunction. Tissue engineering technology may
provide a potential strategy for skeletal muscle regeneration into
metal joint prostheses. Here, a porous titanium (Ti) alloy scaffold
coated with carbon nanotubes (CNTs) and mesoporous silica nanoparticles
(MSNs) through electrophoretic deposition (EPD) was designed as a
mechano-growth factor (MGF) carrier. This two-layered coating exhibits
a nanostructured topology, excellent MGF loading, and prolonged release
performance via covalent bonding to improve myoblast
adhesion, proliferation and myogenic differentiation in porous Ti
alloy scaffolds without cytotoxicity. The Akt/mTOR signaling pathway
plays a key role in this process. Furthermore, in vivo studies show that the scaffold promotes the growth of muscle, rather
than fibrotic tissue, into the porous Ti alloy structure and improves
muscle-derived mechanical properties, the migration of satellite cells,
and possibly immunomodulation. In summary, this nanomaterial-coated
scaffold provides a practical biomaterial platform to regenerate periprosthetic
muscle tissue and restore comparable motor function to that of the
natural joint.
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