Efficient chemical catalyst is becoming a research hotspot in isomerization of glucose to fructose, because the chemical catalyst rather than enzyme has a wider operating temperature range, a longer lifetime and a higher resistance to impurities. The most commonly used chemical catalysts for isomerization of glucose to fructose can be divided into five principal groups, such as homogeneous bases, heterogeneous bases, Lewis acids, aluminates and subcritical water. Thus, the focus of this review is mainly on isomerization of glucose to fructose by using chemical catalysts and mechanistic aspects of the isomerization reaction in order to gather maximum information in one manuscript for a better comprehension of the technological characteristics and specificities of fructose synthesis.
Pharmacokinetics (PK), as a significant part of pharmacology, runs through the overall process of the preclinical and clinical research on drugs and plays a significant role in determining the material basis of efficacy and mechanism research. However, due to the limitations of classical PK, cellular PK was put forward at the historic moment and developed rapidly. Many novel and original technologies have been innovatively applied to the cellular PK research, thereby providing a powerful technical support. As a novel field of PK research, cellular PK expands the research object and enriches the theoretical framework of PK. It provides a new perspective for elucidating the mechanism of drug action and the dynamic process of drug in the body. Furthermore, it provides a scientific basis and guiding significance for the development of new drugs and the guidance of clinical rational drug use. Cellular PK can explain the dynamic process of certain drugs (e.g., antineoplastic drugs and antibiotics) and the disposition kinetics characteristics in some specific tissues (e.g., brain and tumor) in a clearer and more accurate manner. It is a beneficial supplement and perfection of traditional PK. In the future, traditional and cellular PKs will complement each other well and improve into an all-around research system in drug developments. Briefly, this paper reviews the conceptual development of cellular PK and key associated technologies, comments its main functions and applications, and looks forward to the important pioneering significance and promising value for the development of PK.
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