Rhodium-catalyzed C–H activation
of arenes has been established
as an important strategy for the rapid construction of new bonds.
On the other hand, ring-opening of readily available cyclopropanols
has served as a driving force for the coupling with various nucleophiles
and electrophiles. Nevertheless, these two important areas evolved
separately, and coupling of arenes with cyclopropanols via C–H
activation has been rarely explored. In this work, the oxidative coupling
between arenes and cyclopropanols has been realized with high efficiency
and selectivity under Rh(III)-catalysis, providing an efficient route
to access β-aryl ketones. Moreover, the C–H bond has
been extended to benzylic C–H bonds.
Direct and efficient synthesis of 1-naphthols has been realized via Rh(III)-catalyzed C-H activation of sulfoxonium ylides and subsequent annulation with alkynes, where the sulfoxonium ylide functioned as a new traceless bifunctional directing group. This reaction occurred under redox-neutral conditions with a broad substrate scope.
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