A rhodium(I)-catalyzed allenic Alder ene reaction to prepare cross-conjugated trienes has been discovered. The scope and limitations are currently being investigated, and the results obtained to date are reported on. This method shows enticing functional group compatibility by tolerating terminal and internal alkynes, hydroxyl, sulfonamide, ether, and diester groups. Progress has been made to increase the stereoselectivity of the olefinic side chain via an unprecendented iridium(I) catalyzed Alder-ene reaction.
Tandem azidination- and hydroazidination-Huisgen [3 + 2] cycloadditions of ynamides are described here. These processes are regioselective and chemoselective, leading to the synthesis of chiral amide-substituted triazoles.
A one-pot synthesis of amide-substituted triazoles from alkyl bromides and ynamides is described here along with syntheses of novel bis-ynamides and their applications in [3 + 2] cycloadditions with azides to construct unique bis-triazoles.
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