Diterpenoids are the major group of antimicrobial phytoalexins in rice 1,2 . Here we report the discovery of a rice diterpenoid gene cluster on chromosome 7 (DGC7) encoding the entire biosynthetic pathway to 5,10-diketo-casbene, a member of the mono-cyclic casbene-derived diterpenoids. We revealed that DGC7 is regulated through MeJA mediated epigenetic control directly by JMJ705 3 . Functional characterization of pathway genes revealed OsCYP71Z21 to encode a casbene C10 oxidase, sought after for the biosynthesis of an array of medicinally important
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