Introduction: As the prevalence of stress is rising rapidly among the community, it is important to understand their stressors and coping strategies for creating a psychological-friendly environment for the students in the future. The study aim was to explore the stress level, stressors, and coping strategies among first year medical students in Malaysian public universities and factors contributed to the stress at the end of year. Methodology: A multicenter cross-sectional study involving four Malaysian public universities. The 12-item General Health Questionnaire (GHQ-12), Medical Student Stressor Questionnaire (MSSQ) and Brief COPE inventory were self-administered to measure stress level, sources of stress and coping strategies respectively among the participants. Calculated sample size was 387. Results: Out of 387 selected participants, 359 (92.7%) responded to this survey. This study found that the prevalence of distressed first year medical students at the end of year was 50%. The major stressors across the universities were academic-related issues. The top five coping strategies were religion, active coping, positive reinterpretation, acceptance and planning. University, parent income, and academic, group activities, and desire related stressors were significant factors contributing to the students’ stress (p-value < 0.05). Conclusion: This study found that there was a high prevalence of distressed among first year medical students at the end of year, the major stressors were related to academic and contributing factors of stress were related to university, coping strategy, types of stressor and parent income status. Training first year medical students on adaptive coping strategies, managing stressors, and improving peer-group supports to the students will help to improve this condition.
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