Uncontrolled bleeding following trauma is associated with a high risk of death. Here, an emerging kaolinite nanoclay composite (iron oxide-kaolinite, α-Fe 2 O 3 -kaolin KAc ) is developed, based on the natural hemostat hematitum used in traditional Chinese medicine to effectively control hemorrhage. α-Fe 2 O 3 -kaolin KAc stops bleeding in ≈183 ± 16 s and exhibits higher hemostatic activity than the related compounds FeOOH-kaolin KAc (298 ± 14 s), γ-Fe 2 O 3 -kaolin KAc (212 ± 11 s), and Fe 3 O 4 -kaolin KAc (218 ± 15 s). This rapid effect is attributed to efficient absorption of the fluid in blood, activation of blood platelets, and induction of the coagulation cascade by kaolinite and the aggregation of red blood cells induced by α-Fe 2 O 3 . α-Fe 2 O 3 -kaolin KAc shows slight hemolysis (<0.11%) as compared to kaolinite (30%), which accelerates wound healing. The biocompatibility, hemostatic activity, and low cost of α-Fe 2 O 3 -kaolin KAc make it a safe and effective agent for preventing massive blood loss after traumatic injury.

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The novel connection identified between miR-125a-5p and CD147 suggests a new diagnostic and prognostic role for miR-125a-5p and that CD147 inhibition may be a candidate therapeutic target in the therapy of for TC.

Whole-genome re-sequencing of weedy rice from southern China reveals that weedy rice can originate from hybridization of domesticated indica and japonica rice. Weedy rice (Oryza sativa f. spontanea Rosh.), which harbors phenotypes of both wild and domesticated rice, has become one of the most notorious weeds in rice fields worldwide. While its formation is poorly understood, massive amounts of rice genomic data may provide new insights into this issue. In this study, we determined genomes of three weedy rice samples from the lower Yangtze region, China, and investigated their phylogenetics, population structure and chromosomal admixture patterns. The phylogenetic tree and principle component analysis based on 46,005 SNPs with 126 other Oryza accessions suggested that the three weedy rice accessions were intermediate between japonica and indica rice. An ancestry inference study further demonstrated that weedy rice had two dominant genomic components (temperate japonica and indica). This strongly suggests that weedy rice originated from indica-japonica hybridization. Furthermore, 22,443 novel fixed single nucleotide polymorphisms were detected in the weedy genomes and could have been generated after indica-japonica hybridization for environmental adaptation.

Nanoclay can be incorporated into emerging dual functional drug delivery systems (DDSs) to promote efficiency in drug delivery and reduce the toxicity of doxorubicin (DOX) used for thyroid cancer treatment. This paper reports the expansion of the basal spacing of kaolinite nanoclay was expanded from 0.72 nm to 0.85 nm, which could provide sufficiently spacious site for hosting doxorubicin molecules and controlling the diffusion rate. A targeted design for papillary thyroid cancer cells was achieved by introducing KI, which is consumed by the sodium-iodide symporter (NIS). As indicated by MTT assays, confocal laser scanning microscopy and bio-TEM observations, methoxy-intercalated kaolinite (KaolinMeOH) exhibited negligible cytotoxicity against papillary thyroid cancer cells. By contrast, DOX-KaolinMeOH showed dose-dependent therapeutic effects in vitro, and KI@DOX-KaolinMeOH was found to act as a powerful targeted therapeutic drug. Furthermore, active and passive targeting strategies played a role in the accumulation of the drug molecules, as verified by an in vivo bio-distribution analysis.