Clients with severe mental illness and substance use disorder (i.e., dual disorders) frequently have contact with family members, who may provide valuable emotional and material support, but have limited skills and knowledge to promote recovery. Furthermore, high levels of family conflict and stress are related to higher rates of relapse. The present study was a two-site randomized controlled trial comparing a comprehensive, behaviorally-based family intervention for dual disorders program (FIDD) to a shorter-term family psychoeducational program (FPE). The modal family was a single male son in his early 30s diagnosed with both alcohol and drug problems and a schizophrenia-spectrum disorder participating with his middle-aged mother, with whom he lived. Initial engagement rates following consent to participate in the study and the family intervention programs were moderately high for both programs (88% and 84%, respectively), but rates of longer term retention and exposure to the core elements of each treatment model were lower (61% and 55%, respectively). Characteristics of the relatives were the strongest predictors of successful initial engagement in the family programs with the most important predictor being relatives who report higher levels of benefit related to the relationship with the client. Subsequent successful exposure to the family treatment model was more strongly associated with client factors, including less severity of drug abuse and male client gender. The results suggest that attention to issues of Address correspondence to: Kim T. Mueser, Ph.D., Dartmouth Psychiatric Research Center, Main Building, 105 Pleasant St., Concord, NH 03301, FAX (603) 271-5265, Email: kim.t.Mueser@dartmouth.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. People with severe mental illnesses (SMI) such as schizophrenia and bipolar disorder have a high prevalence of co-occurring substance use disorders or dual disorders (Mueser et al., 2000;Regier et al., 1990). Clients with dual disorders have a worse course of psychiatric illness than persons with SMI alone, including more frequent relapses and rehospitalizations, homelessness, poor health, legal problems, and increased depression, hopelessness, and suicide (Drake, O'Neal, & Wallach, 2008;Kavanagh et al., 2004). While progress has been made on development and validation of integrated treatment models for co-occurring disorders in this population (Drake et al., 2008;Kavanagh & Mueser, 2007), the results from different controlled studies are inconsistent and improvements are often modest at best (Cleary, Hunt, Mat...