EAS joins an increasing number of proteins that undergo a disorder-->order transition in carrying out their normal function. This report is one of the few examples where an amyloid-like state represents the wild-type functional form. Thus the mechanism of amyloid formation, now thought to be a general property of polypeptide chains, has actually been applied in nature to form these remarkable structures.

No abstract

2-Amino-5,10,15,20-tetraarylporphyrins react with formaldehyde to give good yields of the corresponding octaaryl derivatives of the Troger's base analogue in which two porphyrins are covalently linked by a diazocine bridge; the X-ray crystal structure of the bis(tetraphenylporphyrinato)dipalladium(ii) derivative 6 reveals a concave chiral cavity with two metal ion binding sites suitable for ditopic interactions with guest molecules.

No abstract

A cyclic trimeric porphyrin host has been synthesised with alkyne-platinum-alkyne linkages; binding of the octahedral aluminium tris [3-(4-pyridyl)actylacetonateJ guest ligand into the complementary cavity of the host induces an asymmetry which is readily detected by NMR spectroscopy. The ligand complementarity unambiguously establishes the structure of this complex artificial receptor, but did not lead to an effective templated synthesis. A platinum-linked tetramer was also tentatively identified, but the absence of a suitably complementary ligand reduces the confidence that can be placed in this larger, and highly flexible, structure. These results demonstrate the strengths, and limitations, of metal coordination chemistry for assembling supramolecular architectures.Paper 5/01075F