A simple one-pot, two-step approach to 2,4,5-trisubstituted imidazoles has been developed commencing from α-methylene ketones and primary alcohols.Using an environmentally friendly, inexpensive, and readily available iodine-based system, a series of trisubstituted imidazoles were prepared in moderate to good yields under mild reaction conditions. 2,4,5-Trisubstituted imidazoles have been known for over 100 years 1 and are recognized for their anti-
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