A simple preparation of sodium impregnated on activated chicken eggshells (Na-ACE) as a solid base material for substituted chalcones synthesis is presented. After characterization using FTIR, XRD, SEM, EDS and total basicity, the catalyst was applied in Aldol condensation to produce corresponding chalcones 3a-3j. Confirmation of products structure has been done by FTIR, UV-Vis and MS instruments. Reaction can be carried out in relative short time with ethanol as the best solvent and gave the highest yield of 95 %. This research presented a facile synthesis of chalcone derivatives, the prominent class of organic compounds with interesting biological activities.
Cannabidiol (CBD) is a naturally occurring phytocannabinoid, approved for use in the US and other countries for the treatment of seizures associated with Dravet syndrome, Lennox-Gastaut syndrome and tuberous sclerosis...
A genomic and bioactivity informed analysis of the metabolome of the extremophile Amycolatopsis sp. DEM30355 has allowed for the discovery and isolation of the polyketide antibiotic tatiomicin. Identification of the biosynthetic gene cluster was confirmed by heterologous expression in Streptomyces coelicolor M1152. Structural elucidation, including absolute stereochemical assignment, was performed using complementary crystallographic, spectroscopic and computational methods. Tatiomicin shows antibiotic activity against Gram-positive bacteria, including methicillin resistant Staphylococcus aureus (MRSA). Cytological profiling experiments suggest a putative antibiotic mode-of-action, involving membrane depolarisation and chromosomal decondensation of the target bacteria.
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