Coronary heart disease (CHD) is one of the main diseases causing morbidity and mortality globally, with oxidative damage and lipid peroxidation associated with oxidative stress and atherosclerosis. Cinnamomum migao is a Miao ethnomedicine that has been shown to provide relief from CHD symptoms. A gas chromatograph-mass spectrometer (GC-MS) was used to determine the chemical components of ten batches of migao fatty oil (MFO), yielding a total of 35 chemical constituents. The antioxidant activity of MFO in vitro was assessed using the DPPH• and ABTS• + assay methods, and both indicated good antioxidant activity. The network pharmacology predicted the active constituents of MFO and their therapeutic influence on the mechanism of oxidative damage-induced coronary heart disease (OD-CHD). Six compounds were discovered in MFO, including tau-cadinol acetate and dodecanoic acid, which may play a role in OD-CHD by acting on lipids and atherosclerosis, the PI3K-Akt signalling pathway, and other pathways. In conclusion, our study lays the foundation for investigating the use of MFO in the treatment of OD-CHD.
Migao volatile oil (MVO), a traditional Chinese medicine extract, exerts
a curative effect on coronary heart disease (CHD). In this study, gas
chromatography-mass spectrometry (GC-MS) was used to determine the
fingerprints of 10 MVO batches, and 27 common components were
identified. The anti-CHD activities of the different MVOs were
determined using ELISA kits, and haematoxylin and eosin staining was
used to assess the histopathological injury in myocardial tissues. Three
mathematical models were used to analyse multiple bioactive indices, and
an anti-CHD-guided spectrum-effect relationship approach was developed
to discover MVO quality control (QC) markers. α-phellandrene, p-cymene,
1,8-cineole, linalool, α-terpineol, α-cubebene, α-copaene, α-humulene,
dihydroagarofuran, and δ-cadinene all showed good affinity for target
proteins connected to CHD, showing their potential as QC markers. Based
on the anti-CHD-guided spectrum-effect relationship approach, a
bioactive constituent-based holistic QC method was successfully
developed for MVO, which could provide a valuable reference for related
QC research.
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