Abstract-Microfluidic driving and controlling techniques are fundamental and important in microfluidic applications.Traditional reagent driving systems of microfluidic chips such as syringe pump and piezoelectric actuator have their inherent shortcomings. Syringe pumpis easy to deformation and screw motion is unstable mayaffect flow rate. Whilethe flow range of piezoelectric actuator is too narrow.To solve these problems we establisheda constant pressure pump by maintaining stable pressure in a cylinder through the switch of electromagnetic valves, and then liquidin the pressurized reservoiris driven out. A simple PID algorithm is utilized to balance cylinder pressure,while flow rate is measured by a flow sensor. This setupcontains a wireless module that can communicate with a PC through Wi-Fi. We use 50μminner diameter flow resistors with different lengths to verify the relationship among flow rate, flow resistor length and pressure drop.The pump could generate a constant pressure in cylinder and the fluctuation of liquid flow is small.This system can be used as injection system of microfluidic chips and it can also be applied to other biochemical reaction. Operation is easy and users can control the system at a distance.
Abstract. A stable pressure driving system was designed in this paper, which can be used in Microfluidic Chips to driving reagents. Herein, two embedded controller units are used to control the stability of the reagent bottles pressure, for driving the reagents flow steady on the microfluidic chips. All parameters of system can be set by a friendly upper computer interface, and the upper and lower computer interactive communication via Wi-Fi. Y-junction microfluidic chip was taken to generate water-in-oil droplets that can be observed by Microfluidic Optical Detection Platform. Through the reagent bottles pressure control waveforms and the distribution of droplets sizes to verify the stability and reliability of stable pressure driving system. This convenient and practical system can be widely used in the reagents driving of Microfluidic Chips, and easy to implement automation may one day help enable the realization of the intelligent laboratory.
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