Background: Aquaporin 4 has been implicated in fluid homeostasis and imbalance during cerebral ischemia. The M1 isoform of AQP4 is found to be highly expressed in cerebral ischemia. Results: AQP4 M1 transcript is observed to be highly modulated by miR-130a during brain edema. Conclusion: miR-130a is a transcriptional repressor of AQP4 M1 promoter. Significance: miR-130a could be useful in regulating AQP4 expression in brain ischemia.
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