EOSINOPHILS IN PYRIDOXINE DEFICIENCY139 data presented in the graph that the rates of inactivation of this thermophilic virus are very similar to those of the phage systems reported by Xanavutty(2) and Smith and Krueger ( 3 ) . However, the temperatures at which the phage becomes susceptible to inactivation are much higher than those of the other reported phages. The virus is quite stable a t 70°C but above this temperature the curves become concave. The most rapid inactivation occurs in the first half hour at temperatures above 80°C with a decided decrease in rate for the remainder of the period. There is no evidence of plaque formation after exposure to 100°C for 60 minutes and the virus is assumed to be completely destroyed.This virus begins to be inactivated at about 75 "C: at which temperature the thermophilic phages reported by Koser ( 5 , 6 ) and Adant ( 7) were completely destroyed. These data bear out the hypothesis that the virus used in this investigation is more heat resistant than any previously reported. Summary. A thermophilic bacteriophage has been isolated which is inactivated by heat at a rate which is not constant but decreases with time. The phage remains viable after two hours exposure at 95"C, but is destroyed at 100°C, indicating that it is much more heat resistant than phages previously reported.
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