Pseudo-peptides (pGlu-His-amphetamine, pGlu-His-Proamphetamine and pGluamphetamine) were subjected to enzymatic degradation by porcine serum and brain homogenate. The enzymic digests were (qualitatively) analyzed by the "Finger-prints" technique to provide evidence for the presence of free pyroglutamic acid and also quantitatively by HPLC to provide evidence for the presence and yield of free amphetamine. The stability in vitro toward enzymes of serum and brain homogenate of a new type of drug based on the combination of a peptide moiety (TRH) with a non peptide psycho-tropic moiety (amphetamine) is considered and discussed.
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