Viruses continued to emerge and bring challenges to the global public health system with emerging viruses with respiratory contagion. Previous studies have shown that the increased incidence of certain viral respiratory infections, including influenza and coronavirus, is associated with low levels of Vitamin D, zinc and iron. Elements such as iron, zinc and Vitamin D influence adaptive immunity by inhibiting the proliferation of B cells with differentiation and secretion of immunoglobulins that will supply the proliferation of T cells and this will result in a more pro-inflammatory response change.
Purpose
To evaluate the oxidative stress in swine neonates submitted to hypoxia.
Methods
Ten large white piglets, healthy newborns, of both sexes, were divided into
two groups and submitted to an experimental hypoxia protocol with reduced
inspired oxygen fraction. The hypoxia group, composed of six animals, was
submitted to oxygen reduction for 180 min. The animals in the control group,
n = 4, were handled and evaluated simultaneously, but without oxygen
reduction.
Results
180 min after the start of the hypoxic insult, a significant difference was
observed in the oximetry, and heart rate of the hypoxia group was compared
to the control group (p<0.05). There was no significant difference in the
oxidative stress analyses. Reduced glutathione (GSH), superoxide dismutase
(SOD), catalase (CAT), lipid peroxidation (TBARS), protein carbonyl (PC),
and myeloperoxidase (MPO) in the piglets’ brain tissue were analyzed.
Conclusions
Hypoxia causes adverse effects in swine neonates, although there is a natural
physiological resistance of swine neonates to respond to this insult.
Analyses of GSH, SOD, CAT, TBARS, MPO, and PC were tabulated and are
presented as parameters for further studies to be carried out on an animal
model of swine hypoxia.
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