Background: Hypoalbuminemia is associated with the nutritional status of patients with type 2 diabetes mellitus (DM2); it is related to oxidative stress and alterations in lipid and protein metabolism, and is a risk factor for mortality in the critically ill patient. Furthermore, DM2 has been associated with an increase in infection-related mortality. We explored the association of these metabolic conditions with mortality and related factors in patients with nosocomial pneumonia. Methods: We included 120 patients with nosocomial pneumonia in a referral hospital; demographic and clinical data were obtained. Data were compared by χ 2 and logistic regression analysis. Results and conclusions: Mortality of patients with hypoalbuminemia was 50%; 43/46 (91.2%) patients who died had hypoalbuminemia (p = 0.0001). DM2 was present in 59.2% of patients, and was significantly associated with hypoalbuminemia (p < 0.05). Other associated factors were mechanical ventilation (91.7%), higher Candida Score, higher incidence of acute renal failure, and higher requirements of FiO 2. Results showed that low albumin levels were an independent mortality factor.
Introducción: El músculo esquelético cambia de acuerdo con el envejecimiento, la inflamación y el desequilibrio hormonal que conduce a la pérdida de masa y fuerza muscular, que se han asociado a sarcopenia, alteraciones metabólicas y osteoporosis. Material y métodos: Estudio prospectivo, analítico, en pacientes con osteoporosis primaria; se realizaron mediciones antropométricas, perfil metabólico, hormonal, mineral, pruebas de sarcopenia y bioimpedancia segmental. Se correlacionó con r de Pearson o rho de Spearman y regresión lineal. Resultados: Se analizaron 14 pacientes con osteoporosis. Se encontró correlación positiva de niveles de folato y la cantidad consumida de calcio al día con mayores valores en densitometría en cuello; factor de crecimiento similar a la insulina-1 (IGF-1) e índice IGF-1 con cadera total; ambas con significancia estadística. Se encontró menor evolución de osteoporosis en pacientes con mayor peso actual, mayor cantidad de músculo y con mayor masa ósea. Menores densidades minerales a nivel de cuello se asociaron con mayor índice de Charlson, mayor número de partos, lactancia al seno materno, mayor edad metabólica, mayor perímetro abdominal y sarcopenia. Conclusión: Los indicadores del rendimiento físico y fragilidad se han asociado con salud ósea. La fuerza muscular, cantidad de masa ósea, microarquitectura ósea y masa magra pueden ser modificados por variables metabólicas y hormonales como el IGF-1.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.