The rat adrenal gland is poorly parasitized during the experi mental infection with Y strain of Trypanosoma cruzi. In both cortical and medullary regions, the parasitism peaked at day 10 and was characterized by the predominance of single amastigotes over nests containing 2 or more parasites. After day 10 of infec tion, the tissue parasitism dropped rapidly to become practically null at day 32 of infection. In cortical tissue, the amastigotes occurred mainly inside the endocrine cells. In the medulla, they found mainly in glial cells and non-identified stromal cells. In both cortex and medulla, inflammatory processes were found till day 20 of infection. Our data do not support the hypothesis that a corticoid rich environment would favor T. cruzi parasitism in adrenal medulla.Résumé : La glande surrénale chez le rat au cours de la trypanosomiase américaine expérimentale : étude immunocytochimique du parasitisme tissulaire.La glande surrénale est peu parasitée au cours de l'infection expérimentale avec la souche Y de Trypanosoma cruzi. Dans le cortex comme dans la médullaire, le parasitisme atteint son maximum le 10e jour d'infection et est caractérisé par une prédo minance d'amastigotes isolés sur les sites contenant deux ou plu sieurs parasites. Après le 10e jour, le nombre de parasites dans la glande tombe rapidement et devient pratiquement nul après
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