Diabetes mellitus can result in hyperglycemia caused by insufficient insulin secretion or insulin resistance. As such, plant extracts that exert a hypoglycemic effect with limited side effects are of interest to the medical and healthcare fields. The hypoglycemic effect of polysaccharides extracted from the branches of Actinidia arguta was explored in mice in this study. Sixty male Kunming mice were subsequently randomly assigned to one of six groups. The body weight, fasting blood glucose level, serum lipids, and oxidative stress parameters were assessed weekly during the 28-day study period. Pancreatic tissue from sacrificed mice was harvested at the end of the study and dissected for analysis. Polysaccharide AABP3 prevented body weight loss and decreased the fasting blood glucose level in diabetic mice compared with control mice. It also had a beneficial effect on serum dyslipidemia and oxidative stress parameters and was comparable in its protective effect to metformin. Histopathological examination of the pancreas revealed that AABP3 could protect and ameliorate pancreatic damage that may occur in diabetes mellitus in mice. AABP3 may be considered a potential candidate for developing a functional food or natural product for treating diabetes and its complications.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.