The data from this study demonstrate that the CB2-selective cannabinoid agonist JWH015 increases aqueous humor outflow facility. The results also indicate that functional CB2 cannabinoid receptors are expressed in trabecular meshwork cells, and these receptors are involved in the enhancement of outflow facility induced by JWH015.
Herein, ditopic ligand DTA comprised of terpyridine and acetylene segments with only one aromatic π-conjugated building block was designed and synthesized. Driven by metal-ligand coordination interactions, we presented that the use of metal salts can direct the self-assembly of DTA in the generation of fluorescent and electrochemical polymers that entrapped water to form ambidextrous hydrogels. These were characterized by several approaches including fluorescent titrations, UV-vis, circular dichroism, and X-ray diffraction spectra as well as scanning electron microscopy and transmission electron microscopy experiments. DTA can selectively recognize Zn ions and gelate water in the presence of ZnCHO (zinc lactate), giving Zn-specific fluorescent metallogels. Otherwise, DTA/Cu(OAc) forms nonfluorescent, electrochemical, and chiral hydrogel that responds to multiple stimuli such as heat, light, shearing, electrolysis, and reducer. The ion-controlled gelation approach, morphology, rheology, as well as fluorescent and chiroptical properties of DTA was studied in detail. Hence, our work demonstrated for the first time the crucial role of metal salts in the supramolecular polymerization and corresponding properties, in which symmetry breaking played an important role for the dynamic assembly difference.
We have developed an integrated instrument combining deep ultraviolet laser ionization mass spectrometry (DUV-LIMS) and infrared multiphoton dissociation (IR-MPD) spectroscopy, abbreviated as DUV-IR. The 177.3 nm DUV laser (7 eV single-photon energy) has short pulse duration (15 ps) and appropriate pulse energy (∼20 µJ), which is found to be highly efficient for low-fragment photoionization of neutral metal clusters and molecules. A home-made cluster source is designed with an adjustable formation channel suitable for the generation of different cluster series. The well-aligned components of the reflection time-of-flight mass spectrometer, as well as the coaxial design of DUV laser and molecular beam, bring forth high sensitivity and high resolution of the DUV-LIMS. Taking these advantages, well-resolved neutral Vn (n = 1–43) and (Benzene)n (n = 1–25) clusters have been generated free of fragmentation. In addition to the generation and detection of neutral clusters, a fast-flow reaction tube is also designed downstream of the cluster source allowing to study their reactivity. In particular, a broad-range tunable IR laser (1.3–16 µm) is coupled with the DUV laser to attain IR-MPD spectroscopic analysis. This integrated system offers a general protocol to prepare various clusters to study their gas-phase reactivity and to determine their structures.
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