FBXO11 expression is down‐regulated in various tumors, but its role in hepatocellular carcinoma remains unclear. Here, we examined the role of FBXO11 in hepatocellular carcinoma cell stemness. FBXO11 overexpression decreased Snail protein levels by directly interacting with Snail and promoting Snail degradation through the ubiquitin‐proteasome system. Overexpression of Snail rescued the inhibitory effect of FBXO11 overexpression on cell stemness.
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