With the global escalation of the aging process, the research on aging mechanisms and anti-aging strategies has become a hot spot. As the most external organ of the human body, skin can be used as an ideal organ for the study of endogenous and exogenous aging. Bamboo leaf flavonoids (BLF) possess a variety of biological effects such as antioxidant, anti-bacterial, anti-inflammatory, lipid-lowering, anti-radiation, and anti-aging. However, it is still unclear whether they can delay skin aging. This study aimed to analyze the inhibitory effect of BLF on skin aging and explore their molecular mechanisms. We found that 10–40 μg/mL BLF significantly inhibited the senescence of HaCaT cells induced by AAPH, which might be related to their antioxidant and anti-inflammatory abilities. Further mechanism studies showed that mitogen-activated protein kinase (MAPK), especially the p38 MAPK pathway, was the key to BLF to alleviate the senescence of HaCaT cells. In addition, autophagy was also involved in the anti-senescence effect of BLF. The results were also verified in UVB-induced photoaging mice. Therefore, BLF can be used as a potential therapeutic agent to intervene skin aging in vitro and in vivo.
The technology of coal breaking and punching by a high-pressure water jet can increase the permeability of coal seam and prevent gas explosion accidents. As one of the key components of this technology, the structural parameters of the nozzle have an important effect on the performance of the water jet. At present, the relationship between multiple optimization indexes and structural parameters of the nozzle is mostly studied separately. In fact, the influence of the nozzle structural parameters on different optimization indexes is different. When there are multiple optimization indexes, they should be considered collaboratively to achieve the best water jet performance of the nozzle. Therefore, a multi−objective collaborative optimization method is proposed which takes the maximum velocity in X-axis and effective extension distance in Y-axis as the performance evaluation indexes of the water jet. The numerical simulation of the nozzle jet is carried out by computational fluid dynamics(CFD) method, and an orthogonal test database is established. The weight of multi-objective is analyzed, and the key structural parameters of the nozzle are optimized by the combination of BP (back propagation) neural network and genetic algorithms. The results show that the primary and secondary sequence of each structural parameter on is γ>θ>l∕d, which could reflect the comprehensive influence on the maximum velocity in the X-axis and effective extension distance in the Y-axis. The optimal structural parameters of the nozzle are, θ = 42.512°, l/d = 2.5608, γ = 12.431°. The field erosion experiment shows that compared with the original nozzle, the water jet performance of the optimized nozzle has been improved, the punching depth has been increased by 72.71%, and the punching diameter has been increased by 106.72%. This study provides a certain reference for the design and optimization of coal breaking and punching nozzle.
Aging can lead to the occurrence of many degenerative diseases, and the most intuitive consequences are mainly manifested on the skin, which is affected by both endogenous and exogenous aging...
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