RESUMOAs doenças proliferativas histiocíticas são desordens conhecidas no cão e que possuem inúmeras origens, muitas ainda não completamente elucidadas. O complexo sarcoma histiocítico pode ser dividido em três principais tipos: sarcoma histiocítico localizado, sarcoma histiocítico disseminado e sarcoma histiocítico hemofagocítico. O objetivo desse trabalho foi relatar um caso de sarcoma histiocítico disseminado acometendo múltiplas localizações em um Rotweiler. O animal foi atendido pelo Hospital Veterinário da Universidade Federal de Uberlândia (HV-UFU) com a queixa de um aumento de volume em membro posterior esquerdo e presença de uma massa em placa na região de glândulas mamárias torácica caudal à inguinal esquerda. Foi realizada a punção aspirativa por agulha fina da massa e obteve-se o diagnóstico de sarcoma histiocítico. Após dois dias de piora clínica o animal foi eutanasiado e então o Laboratório de Patologia Animal do HV-UFU realizou o exame de necropsia. Ao realizar o exame foi observada linfadenomegalia em linfonodos axilar e inguinal esquerdos, e a presença de uma massa aderida à parede dorsal de cavidade abdominal. Os órgãos alterados foram coletados e após realização de exame histopatológico foi confirmado o diagnóstico de sarcoma histiocítico com metástase para linfonodo axilar e inguinal esquerdos. PALAVRAS-CHAVE: citopatológico, complexo sarcoma histiocítico, neoplasma, metástase.

RESUMO O melanoma é considerado neoplasia de células redondas, de origem em melanócitos e melanoblastos. É comumente encontrada em mucosa oral e globo ocular, sendo também comum metástases para linfonodos e pulmões. Este trabalho teve por objetivo relatar um caso de melanoma em cão com ocorrência de metástase em locais incomuns. Uma cadela, treze anos de idade, da raça Poodle foi encaminhada para avaliação clínica com nódulo cutâneo na altura do osso radio esquerdo. Após exame citológico diagnosticou-se melanoma e durante a necropsia observou-se metástases em vários tecidos como fígado, coração e sistema nervoso central. No exame microscópico notou-se proliferação de células redondas a alongadas, pouco diferenciadas, arranjadas em manto por vezes em feixes. As células neoplásicas apresentavam citoplasma escasso, e eosinofílico, com raras granulações de coloração marrom. O melanoma é uma neoplasia que pode apresentar metástases em locais incomuns, como fígado, coração e sistema nervoso central, além de linfonodos e pulmões, locais mais frequentemente relatados. PALAVRAS-CHAVE: canino, metástase, neoplasia MELANOMA WITH MULTIPLE METASTASIS IN DOG-CASE REPORT ABSTRACT Melanoma is considered a neoplasia of round cells, originating in melanocytes and melanoblasts. It is commonly found in the oral mucosa and eyeball, and also metastases to lymph nodes and lungs. This work aimed to report a case of melanoma in dogs with metastasis in unusual places. A 13-year-old Poodle dog was referred for clinical evaluation with a cutaneous nodule at the height of the left bone. After cytologic examination, melanoma was diagnosed and necropsy revealed metastases in various tissues such as liver, heart and central nervous system. Microscopic examination revealed proliferation of elongated, slightly differentiated round cells, arranged in mantle, sometimes in bundles. Neoplastic cells had scarce cytoplasm, and eosinophilic, with rare granulations of brown color. Melanoma is a neoplasm that can present metastases in unusual places, such as the liver, heart and central nervous system, as well as lymph nodes and lungs, most frequently reported sites.

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This paper aims to assess the magnitude and profile of deaths from post-COVID conditions in Brazil. Descriptive study based on preliminary data from the 2021 Mortality Information System. Records with ICD code B94.8 as the Basic Cause and with code U09 in some lines of part I or II of the declaration were considered for analysis. The distribution of deaths by geographic region, semester of occurrence, sex, age group, ethnicity/skin color, schooling, and place of occurrence was evaluated. We identified 2,948 deaths from conditions subsequent to COVID-19 were recorded, ranging from 0.5 deaths per 1,000 records in the Northeast Region to 3.6/1,000 in the Midwest Region. More than half occurred among males (58.0%), those aged 60 years or older (66.9%), and whites (51.8%). Conclusion: Deaths from post-COVID conditions had distinct sociodemographic characteristics between regions.

Mast cell tumors are one of the most common neoplasia in dogs and cytopathology and/or histopathology examinations are used for diagnosis. Histologic grading is considered the gold standard test to predict the prognosis of this neoplasia. However, studies have been conducted using the cytological grading system to provide similar information in a faster, less invasive, and more accessible way. This study aimed to investigate cytological graduation and correlate it with histological grading and the survival time of dogs diagnosed with cutaneous mast cell tumors at the Veterinary Hospital of “Universidade Federal de Uberlândia” over five years. For that, cytological and histological slides from 72 animals were reviewed. The statistical methods used were the kappa test for agreement between grading systems, the Kaplan-Meier for survival time, Cox regression for comparison of cytological and histological grades and survival time. The cytological grading when compared to the two-tier histologic grading, high and low grades, had a moderate agreement (kappa 0.566). When the correlation between survival time and the cytological grade was evaluated, there was a higher death rate in the group with high-grade mast cell tumors compared to low grade, pointing to a correlation between survival time and cytological grade (p=0.009). In conclusion, the cytological grade is useful to treatment planning and providing prognostic information that precedes tumor removal, showing a good correlation with the two-tier histologic grading and with the survival time of the animals.

Objective: To analyze the factors associated with hospital mortality due to COVID-19 in Mato Grosso in 2020. Methods: We considered the hospitalization records from March to December 2020, from patients with COVID-19 aged 19 years or older residing in Mato Grosso. Data were obtained from the state government’s system and Hazard Ratios were estimated using the Poisson regression model. Results: Of the 17,523 hospitalization records of COVID-19, 4,147 died (23.7%), with higher risk of death among patients aged 40 years or older, black-brown, indigenous, some comorbidity, who were admitted to the ICU bed, who did not reside in the central macro-region of the state, and who were hospitalized in June and July, those with the highest concentration of hospitalizations for COVID-19. Conclusion: Besides the individual factors, organization and preparation of the care network to attend to severe cases of the disease were associated with risk of death by COVID-19.

Pneumocephalus is a well described disease; it is commonly diagnosed in humans, but the condition is rarely encountered in veterinary medicine. Computed tomography (CT) is the gold-standard diagnostic method for identifying this disease, and other methods (such as necropsy) are rarely described. In this report, we describe necropsy findings of a 10-month-old, mixed-breed dog with intraventricular pneumocephalus. The dog was referred to Laboratory of Animal Pathology of the Federal University of Uberlândia, Brazil, for necropsy after being diagnosed with pneumocephalus upon CT. In the examination, the brain had dilation of both lateral ventricles with empty spaces. Histopathology showed congestion and mineralization only near the lateral ventricles, leading to the diagnosis of pneumocephalus based on the macroscopic findings. The animal also showed sinusitis characterized by nasal discharge and neutrophilic infiltration of nasal sinuses. However, bacterial culture was not conclusive because of contamination of the sample. This is therefore an important report that shows necropsy findings of intraventricular pneumocephalus, which is a rare condition in dogs. By documenting the necropsy findings, we hope to help veterinary pathologists, including those with limited access to diagnostic imaging.

RESUMOO carcinoma de saco anal é uma neoplasia maligna, localmente invasiva e altamente metastática, raramente descrita em felinos. Geralmente se apresenta como um inchaço ou massa decorrente dos sacos anais, que podem invadir profundamente o tecido perirretal. Objetivou-se relatar o caso de um felino de 15 anos de idade, fêmea, apresentando nódulo em região perianal esquerda. O animal foi submetido à biópsia incisional por punch e posteriormente a excisão cirúrgica da neoplasia. Ambos materiais resultantes das biópsias foram encaminhados ao laboratório de Patologia Animal da UFU, onde foram processados, corados por H.E e analisados em microscopia óptica. Microscopicamente observou-se no geral, amostras constituídas por proliferação de células epiteliais, arranjadas em rosetas. Células arredondadas a cuboidais, com citoplasma eosinofílico, moderado a amplo, núcleo central, arredondado, cromatina densa e nucléolo indistinto. Elevado pleomorfismo celular, com acentuada anisocitose e anisocariose. Presença de em média 3 a 4 figuras de mitose por 10 campos de maior aumento, todas as amostras foram compatíveis com diagnóstico de carcinoma de saco anal. A sobrevida do animal foi de aproximadamente um mês após diagnóstico da neoplasia.