By including data from all settings, World Health Organization stroke surveillance can provide data to help plan future resources that meet the needs of the public-health system.
BackgroundRegular physical activity (PA) induces desirable changes in plasma levels of
high- and low-density lipoproteins (HDL and LDL, respectively) and
triglycerides (TG), important risk factors for cardiometabolic diseases.
However, doubts whether intensity and duration have equivalent benefits
remain.ObjectiveTo assess the association of PA intensity and duration with HDL, LDL and TG
levels.MethodsCross-sectional study with 12,688 participants from the Brazilian
Longitudinal Study of Adult Health (ELSA-Brasil) baseline, who were not on
lipid-lowering medication. After adjustment for important covariates,
multiple linear regression was used to assess the association of PA
intensity and duration with HDL, LDL and TG (natural logarithm) levels.ResultsBoth moderate and vigorous PA and PA practice ≥ 150 min/week were
significantly associated with higher HDL and lower TG levels. Vigorous PA
was associated with lower LDL only on univariate analysis. After
adjustments, moderate and vigorous PA increased mean HDL level by 0.89 mg/dL
and 1.71 mg/dL, respectively, and reduced TG geometric mean by 0.98 mg/dL
and 0.93 mg/dL, respectively. PA practice ≥ 150 min/week increased
mean HDL level by 1.05 mg/dL, and decreased TG geometric mean by 0.98
mg/dL.ConclusionOur findings reinforce the benefits of both PA parameters studied on HDL and
TG levels, with a slight advantage for vigorous PA as compared to the
recommendation based only on PA duration.
OBJECTIVES:To describe the ERICO study (Strategy of Registry of Acute Coronary Syndrome), a prospective cohort to investigate the epidemiology of acute coronary syndrome.METHODS:The ERICO study, which is being performed at a secondary general hospital in Sao Paulo, Brazil, is enrolling consecutive acute coronary syndrome patients who are 35 years old or older. The sociodemographic information, medical assessments, treatment data and blood samples are collected at admission. After 30 days, the medical history is updated, and additional blood and urinary samples are collected. In addition, a retinography, carotid intima-media thickness, heart rate variability and pulse-wave velocity are performed. Questionnaires about food frequency, physical activity, sleep apnea and depression are also applied. At six months and annually after an acute event, information is collected by telephone.RESULTS:From February 2009 to September 2011, 738 patients with a diagnosis of an acute coronary syndrome were enrolled. Of these, 208 (28.2%) had ST-elevation myocardial infarction (STEMI), 288 (39.0%) had non-ST-elevation myocardial infarction (NSTEMI) and 242 (32.8%) had unstable angina (UA). The mean age was 62.7 years, 58.5% were men and 77.4% had 8 years or less of education. The most common cardiovascular risk factors were hypertension (76%) and sedentarism (73.4%). Only 29.2% had a prior history of coronary heart disease. Compared with the ST-elevation myocardial infarction subgroup, the unstable angina and non-ST-elevation myocardial infarction patients had higher frequencies of hypertension, diabetes, prior coronary heart disease (p<0.001) and dyslipidemia (p = 0.03). Smoking was more frequent in the ST-elevation myocardial infarction patients (p = 0.006).CONCLUSIONS:Compared with other hospital registries, our findings revealed a higher burden of CV risk factors and less frequent prior CHD history.
We measured plasma‐derived extracellular vesicle (EV) proteins and their microRNA (miRNA) cargos in normoglycemic (NG), glucose intolerant (GI), and newly diagnosed diabetes mellitus (DM) in middle‐aged male participants of the Brazilian Longitudinal Study of Adult Health (ELSA‐Brazil). Mass spectrometry revealed decreased IGHG‐1 and increased ITIH2 protein levels in the GI group compared with that in the NG group and higher serotransferrin in EVs in the DM group than in those in the NG and GI groups. The GI group also showed increased serum ferritin levels, as evaluated by biochemical analysis, compared with those in both groups. Seventeen miRNAs were differentially expressed (DEMiRs) in the plasma EVs of the three groups. DM patients showed upregulation of miR‐141‐3p and downregulation of miR‐324‐5p and ‐376c‐3p compared with the NG and GI groups. The DM and GI groups showed increased miR‐26b‐5p expression compared with that in the NG group. The DM group showed decreased miR‐374b‐5p levels compared with those in the GI group and higher concentrations than those in the NG group. Thus, three EV proteins and five DEMiR cargos have potential prognostic importance for diabetic complications mainly associated with the immune function and iron status of GI and DM patients.
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