Few cases of dermatosis neglecta have been reported in the medical literature, although the diagnosis is well-known to dermatologists. Recognizing this condition avoids unnecessary, aggressive diagnostic and therapeutic procedures. This case report discusses two cases of this condition in female patients in whom the dermatosis developed as a result of deliberate or unconscious neglect of personal hygiene. Keywords: Adolescent; Adult; Female; Hygiene Resumo: Poucos são os casos de dermatitis neglecta relatados na literatura, apesar de o diagnóstico ser conhecido pelos dermatologistas. Reconhecer o quadro evita condutas diagnósticas e terapêuticas agressivas e desnecessárias. Os autores relatam dois casos de pacientes do sexo feminino nos quais a dermatite se desenvolveu como resultado intencional ou não de negligência com o asseio pessoal.
Psoriasis (PsO) is a chronic, immune-mediated, inflammatory and polygenic dermatosis and may be associated with psoriatic arthritis (PsA). Interleukin 36 (IL-36) has important role in to make the interaction between the innate and adaptive immune response. Variants in genes encoding cytokines can modulate the susceptibility as well as the severity of diseases. This study aims to assess the frequency of IL36G intron C > T (rs13392494) and IL36G 3’untranstaled region (UTR) A > G (rs7584409) single nucleotide variants and their association with susceptibility, joint involvement and severity of PsO in Brazilian patients. The study included 154 patients with PsO and 154 healthy individuals. The IL36G rs13392494 and IL36G rs7584409 were genotyped by the allelic discrimination assay using the real-time polymerase chain reaction (qPCR). The severity of PsO was assessed using the Psoriasis Area and Severity Index (PASI). The rs7584409 variant showed a protective effect in PsO whereas the rs13392494 variant was not associated with susceptibility to PsO. We demonstrated that the G allele of IL36G rs7584409 (dominant model) was associated with 2.3 more chance to PASI > 10, as well as the patients carrying the IL36G rs7584409 GG genotype showed about 5.0 times more chance of PsA than those carrying the AA genotype. The presence of the G allele of the IL36G rs7584409 variant was associated with protection to PsO, higher PASI and the presence of PsA than the A allele, suggesting that this variant may be used as a potential genetic biomarker to predict severity and joint involvement of the PsO.
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