SUMMARY – Premature infants are susceptible to oxidative stress that causes neonatal disease such as retinopathy of prematurity (ROP). Oxidative stress is an imbalance between the production of pro-oxidants and the ability of the body to detoxify their harmful effects by antioxidants. The proliferative phase 2 ROP occurs at around 33 rd postmenstrual week (pmw). The purpose of our study was to evaluate the pro-oxidant/antioxidant status in preterm infants at 33 rd pmw. The study included 59 premature infants. ROP was classified according to the International Classification of Retinopathy of Prematurity. Total oxidative status (TOS), total antioxidant status (TAS), malondialdehyde (MDA) and paraoxonase 1 (PON1) activity were determined spectrophotometrically. The values of the pro-oxidants TOS and MDA were significantly higher in infants with ROP as compared to infants without ROP (p<0.05 both). There were no significant differences in the values of TAS and PON1 between the infants with and without ROP. According to study results, TOS and MDA are good markers of oxidative stress, whereas TAS and PON1 activity are unreliable in assessing antioxidant protection.
Introduction/Objective Currently, analysis of the stability of amputees with diabetes is lacking. The aim of this case study was to examine the effects of unilateral transtibial amputation on the stability and balance confidence of patients with below-knee amputation caused by trauma and diabetes. Methods Seventeen subjects, 12 males and five females, with the average age of 51.47 ± 12.12 years, who use a unilateral transtibial prosthesis, were examined. The balance of 10 traumatic amputees (TTA) and seven diabetic amputees (TDA) was assessed by Activities-Specific Balance Confidence (ABC) scale, Timed Up and Go (TUG) test, and One-Legged Stance Test (OLST). Plantar pressure distribution was recorded using Gaitview AFA-50. Results For 10 TTA and one TDA, ABC scores were > 80%, the mean value of the TUG test was 11 (range: 8.08-23 seconds). All the subjects could stand on the healthy leg, two women with diabetes were unable to stand on the prosthetic leg. The distribution of load between the healthy and the prosthetic leg showed higher overload on the healthy leg (average: 56.62%). Conclusion The data from this case series describe stability problems of people with transtibial amputation. Plantar pressure distribution has the potential to provide information about the properties of stability in the amputees who use prosthesis.
BackgroundEmbryologically, duodenal atresia results from inadequate recanalisation and proliferation of gut epithelius in the 6th week of gestation, while apple-pee atresia of small bowel is a consequence of a vascular accident in subsequent embryonic development, and the two are rather rarely manifested as a joint clinical entity.Case presentationWe present here a 29 week preterm boy admitted to the intensive care unit due to breathing difficulties and low birthweight. Following clinical, radiographic and ultrasound examination, he was diagnosed with duodenal obstruction and subjected to surgical treatment.The exploration of abdominal cavity verified duodenal atresia in the second portion with the absence of third and fourth portions of duodenum, superior mesenteric artery, as well as apple-peel atresia of jejunum. Resection of the apple-peel segment of jejunum was done and the continuity of digestive tube was established by the end-to-end duodeno-ileal anastomosis.ConslusionThis rare case of ours questions the embryology of duodenal atresia suggesting that a mesenteric vascular disruption phenomenon in subsequent embryonic life might be the aetiological factor.
Insulin like growth factor 1 (IGF-1) is a regulator of intrauterine growth, and circulating concentrations are reduced in intrauterine growth-restricted fetuses. The aim of our study was to investigate the relationship between IGF-1 levels in newborns and intrauterine growth, expressed as birth weight (BW). The research was designed as a cross-sectional study. The study included 71 premature newborns, gestational age (GA) ≤33 weeks. Quantitative determination of IGF-1 was performed in the 33 rd post-menstrual week (pmw) to make the measurements more comparable. We used an enzyme-bound immunosorbent test for quantitative determination of IGF-1. Our results showed the mean IGF-1 level in premature newborns in 33 rd pmw to be 23.1±4.56 (range 15.44-39.75) μg/L. There was no difference in IGF-1 values between male (23.1±4.98 μg/L) and female (23.1±4.87 μg/L) newborns. There was no significant difference in the average IGF-1 levels between male and female newborns with BW <50 th and BW >50 th percentile for GA either (p>0.50). Only BW <33 rd percentile newborns had a statistically significantly lower IGF-1 level compared to newborns with greater BW. Based on our results, it is concluded that serum IGF-1 level reflects intrauterine growth only in BW <33 rd percentile newborns. This fact could be used for further therapeutic purposes.
We believe that by correcting the term for determining the levels we can get a significant correlation between low values of insulin-like growth factor -1 and chronic lung disease.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.