Background: Transcatheter aortic valve implantation (TAVI) has become a broadly acceptable alternative to AV surgery in patients with aortic stenosis (AS). New valve designs are becoming available to address the shortcomings of their predecessors and improve clinical outcomes. Methods: A systematic review and meta-analysis was carried out to compare Medtronic’s Evolut PRO, a new valve, with the previous Evolut R design. Procedural, functional and clinical endpoints according to the VARC-2 criteria were assessed. Results: Eleven observational studies involving N = 12,363 patients were included. Evolut PRO patients differed regarding age (p < 0.001), sex (p < 0.001) and STS–PROM estimated risk. There was no difference between the two devices in terms of TAVI-related early complications and clinical endpoints. A 35% reduction of the risk of moderate-to-severe paravalvular leak (PVL) favoring the Evolut PRO was observed (RR 0.66, 95%CI, [0.52, 0.86] p = 0.002; I2 = 0%). Similarly, Evolut PRO-treated patients demonstrated a reduction of over 35% in the risk of serious bleeding as compared with the Evolut R (RR 0.63, 95%CI, [0.41, 0.96]; p = 0.03; I2 = 39%), without differences in major vascular complications. Conclusions: The evidence shows good short-term outcomes of both the Evolut PRO and Evolut R prostheses, with no differences in clinical and procedural endpoints. The Evolut PRO was associated with a lower rate of moderate-to-severe PVL and major bleeding.
Introduction: Obstructive Sleep Apnea is a disease entity that affects many aspects of life, but is often overlooked and underdiagnosed. OSA is defined as episodes of apnea-hypopnea that disturbs not only sleep, but also daytime functioning. Symptoms can be divided into night symptoms (not breathing, snoring, gasping, fragmented sleep) and daytime symptoms (fatigue, low concentration, morning headaches, decreased libido). Moreover, OSA through many mechanisms affects the cardiovascular system and leads to its dysfunction. Purpose: The aim of this study is to draw attention to the often underdiagnosed disease entity, which is OSA, which, if left untreated, may lead to serious complications. Material and methods: In 2022, the PubMed and Google Scholar databases were searched using the following keywords: OSA, apnea, cardiovascular disorders, arrhythmias and heart disease. Works in English with the most recent data have been selected. Summary: OSA is strongly associated with cardiovascular disorders, moreover, in both cases, we find similar risk factors for these disorders. A correlation has been demonstrated between OSA and atrial fibrillation, hypertension, and arrhythmias. On the other hand, OSA is still underdiagnosed and more research is needed to understand the correlation between these diseases.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.