Sixty, relapsing remitting (RR) multiple sclerosis (MS) patients, who underwent treatment with glatiramer acetate (GA), interferon (IFN)-beta 1a, and immunoglobulins (Igs) (20 per treatment group), were assessed for levels of brain-derived neurotrophic factor (BDNF) in the supernatants of unstimulated and stimulated peripheral blood mononuclear cells (PBMCs) in the first year of treatment. Phytohemagglutinin (PHA), anti-OKT3 antibody, myelin basic protein (MPB) and GA were used as stimuli. Cytokine responses by ELISPOT and lymphoproliferative responses were also assessed. The GA-treated MS patient group showed a progressive increase in BDNF levels, from baseline to month three; thereafter, the levels remained stable and significantly greater compared with baseline and controls (ANOVA=P<0.001). IFN-beta 1a had no effect on BDNF production, whereas Igs induced a slight decrease (ANOVA=P<0.04). ELISPOT analysis revealed a significant decrease of IFN-gamma, an increase of interleukin (IL)-4 and IL-5 in GA-treated MS patients, and an increase of IL-10 in patients treated with IFN-beta 1a and GA. No significant correlation was found between BDNF secretion in the supernatants of PBMCs and cytokine response, lesional load, and measures of atrophy. Increased BDNF production related to GA treatment can have implications for understanding the mechanism of action of this immunomodulatory agent, in light of evidence suggesting its effects in promoting neuroprotective immunity in MS patients; however, a clinically measurable effect, especially in terms of an impact on actual disease progression, remains to be established.
This article contributes to the environmental justice debate by analysing the case of the ILVA steel plant in Taranto, Italy. It accounts for the radical polarisation of the public debate between industrialists and environmentalists. These dominant perspectives are polarised but not
politicised. In the reading of the crisis, both fronts adopt similar techno-scientific arguments while failing to problematise the multiple dimensions of environmental injustice and to connect the crisis to broader social relations of production. This article contends, therefore, that the
environmental debate in Taranto unfolds in a post-political situation, where technical narratives prevail at the expense of more political positions. In this context, any attempts to politicise the public debate is either absorbed by the dominant views or marginalised.
The article focuses on the case of the largest steel plant in Europe, located in Taranto (Italy), to argue that its current crisis is not simply dictated by technological or managerial failings. Rather, the article contends that its problems stem from a regulatory crisis and, specifically, from the failure of the deregulation model pursued after the industry's process of privatization. Such a model has hinged upon the logic of a big private firm that, on the one hand, has sought to disembed itself from the socio-institutional context and, on the other, has set and followed its own rules with disruptive effects on the local society and environment, as well as on the plant's economic viability. Such a model entered a crisis when the other socio-institutional actors started to react to the disastrous situation existing in Taranto. To use Polanyian language, a 'double movement' has emerged: disruptive pressures have triggered defensive reactions.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.