No abstract

The formation of cyclopentenones from biomass derivatives has been developed by reacting furfurals with secondary amines using Lewis acid catalysis under batch conditions. The challenge of scaling up these processes leads to the development of a continuous flow procedure for the preparation of trans-4,5-diamino-cyclopentenones using silica-supported copper catalysts. These catalysts exhibited high efficiency and recyclability for the preparation of a broad scope of cyclic enones.

The isolation and structural elucidation of key active compounds from natural sources have grown increasingly in importance, and oleuropein has come to be seen as a potentially valuable natural compound for employment as a starting material for the generation of new compounds with new therapeutic utility. This microreview focuses on the synthetic transformations of oleuropein, together with its structure elucidation and isolation, biosynthesis, biodegradation, and biological properties.

Continuous flow hydrogenation of trans-4,5-diamino cyclopentenones to diamino cyclopentanones and base-promoted elimination originates α-enaminones. The strategy is applied to the short synthesis of reported ATP-sensitive potassium channel agonist.

The presence of sulfur–carbon bonds is transversal to several areas of chemistry, e.g., drug discovery, materials, and chemical biology. However, a lack of efficient and sustainable procedures for the preparation of thioaminals, the N,S-analogues of O,O-acetals, contributes to this functional group often being overlooked by the scientific community. In this work is described the formation of thioaminals in water promoted by copper(II) triflate.