Many efforts have recently been dedicated to developing smart sockets that seek to provide insights into the reduction of standby energy waste coupled to electric appliances. However, not all technical solutions consider the techno-economic benefits in the development. This research presents a hardware solution based on STM32F103 (STM32F103 devices use the Cortex-M3 core, with a maximum CPU speed of 72 MHz) for the development of an energy-efficient smart socket to address the standby energy waste of household electric appliances and associated economic losses. Input-output analysis on monitored voltage and current was employed to assess the performance and examine the precision of the developed system. As it was targeted at facilitating easier operation, the smart socket was developed to be compatible with other remote controllers of household electric appliances. Experimental results indicated that the developed system could measure voltage values accurately to avoid overvoltage for security protection. The measuring unit could monitor current values with high precision to support the energy-saving control. A functional testing was conducted on the prototypes with a lifecycle assessment employed to validate the economic attractiveness of the developed system. Results indicated that the system is user friendly and cost-effective as no extra wiring required and network environment independent. Indeed, indirect fruits, such as lifespan extension and safety enhancement, could also be achieved for appliances.
Novel therapy strategies are crucial for thyroid carcinoma treatment. It is increasingly important to clarify the mechanism of thyroid carcinoma progression. Several studies demonstrate that α-Enolase (ENO1) participates in cancer development; nevertheless, the role of ENO1 in thyroid carcinoma progression remains unclear. In the present study, we found that the expression of ENO1 was upregulated in thyroid carcinoma samples. Proliferation and migration of thyroid carcinoma cells were suppressed by depletion of ENO1; conversely, ENO1 overexpression promoted thyroid carcinoma cell growth and invasion. To elucidate the mechanisms, we found that the hypoxia-related mTOR/HIF1 pathway regulated ENO1 expression. ENO1 regulated the expression of CST1; knockdown of CST1 reversed the tumorigenicity enhanced by ENO1 overexpression. Taken together, our findings provide a theoretical foundation for thyroid carcinoma treatment.
Decarbonising the urban built environment for reaching carbon neutrality is high on the agenda for many cities undergoing rapid expansion and densification. As an important urban form, precincts have been increasingly focused on as the context for urban redevelopment planning and at the forefront for trialling carbon reduction measures. However, due to interplays between the built forms and the occupancy, the carbon performance of a precinct is significantly affected by morphological variations, demographical changes, and renewable energy system deployment. Despite much research on the development of low-carbon precincts, there is limited analysis on aggregated effects of population growth, building energy efficiency, renewable energy penetration, and carbon reduction targets in relation to precinct carbon signature and carbon neutral potential for precinct redevelopment and decarbonisation planning. In this paper, an integrated carbon assessment model, including overall precinct carbon emissions and carbon offset contributed by precinct-scale renewable energy harvesting, is developed and applied to examine the lifecycle carbon signature of urban precincts. Using a case study on a residential precinct redevelopment, scenario analysis is employed to explore opportunities for decarbonising densification development and the carbon neutral potential. Results from scenario analysis indicate that redevelopment of buildings with higher-rated energy efficiency and increase of renewable energy penetration can have a long term positive impact on the carbon performance of urban precincts. Meanwhile, demographical factors in precinct evolution also have a strong influence on a precinct’s carbon neutral potential. Whilst population size exerts upward pressure on total carbon emissions, changes in family types and associated consumption behaviour, such as travelling, can make positive contributions to carbon reduction. The analysis also highlights the significance of embodied carbon to the total carbon signature and the carbon reduction potential of a precinct during densification, reinforcing the notion that “develop with less” is as important as carbon offsetting measures for decarbonising the precinct toward carbon neutrality.
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