Diet provides energy and nutrition for human survival, and also provides various joy of taste. Extensive studies have shown that the major components of diet, such as protein, carbohydrate and fat, play important roles in regulating aging and longevity. Whether other dietary ingredients can help prevent aging and extend longevity is a very interesting question. Here based on recent findings, we discussed dietary plant ingredients that can extend longevity by regulation of metabolism, targeting TRP channels, mitophagy, senescence pathways and circadian rhythms. Better understanding of the detailed effects and mechanisms of dietary ingredients on longevity regulation, would be helpful for developing new intervention tools for preventing aging and aging related diseases.
Supplementary Information
The online version contains supplementary material available at 10.1007/s11130-021-00946-z.
With the increasing frequency of human exposure to blue light, the harmfulness of blue light has received wider attention. The damaging effect of blue light is complex and long‐lasting. In this study, Drosophila melanogaster was used as a model organism to investigate the protective effect of the senolytic drug quercetin on blue light toxicity. As one of the first senolytic drugs discovered, quercetin not only has antioxidant properties, but also has been used to treat various neurological disorders. Our study shows that quercetin can effectively prolong the survival of flies under blue light irradiation, and it significantly increases the egg production of female flies under blue light. In addition, after flies intaking quercetin under blue light, both the spontaneous activity and nutrient metabolism show significant sex‐specificity. The experimental results provide a potentially effective intervention method for organisms to defend against blue light toxicity, and reveal a new function of the senolytic drug quercetin from another perspective.
The decline of Drosophila climbing behavior is one of the common phenomena of Drosophila aging. The so-called negative geotaxis refers to the natural upward climbing behavior of Drosophila melanogaster after it oscillates to the bottom of the test tube. The strength of climbing ability is regarded as the index of aging change of D. melanogaster. At present, many laboratories use the percentage of 10 fruit flies climbing a specific height in 5 s as a general indicator of the climbing ability of fruit flies. This group research index ignores the climbing performance of a single fruit fly, and the climbing height belongs to the concept of vertical distance in physics, which cannot truly and effectively reflect the concept of curve distance in the actual climbing process of fruit flies. Therefore, based on the image processing algorithm, we added an experimental method to draw the climbing trajectory of a single fruit fly. By comparing the differences in climbing behavior of fruit flies under different sex, group or single, oscillation condition or rotation inversion condition, we can find that the K-Nearest Neighbor target detection algorithm has good applicability in fruit fly climbing experiment, and the climbing ability of fruit flies decreases with age. Under the same experimental conditions, the climbing ability of female fruit flies was greater than that of male fruit flies. The climbing track
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