Numerous factors impact on the prognosis of acute myeloid leukemia (AML), among which molecular genetic abnormalities are developed increasingly, however, accurate prediction for newly diagnosed AML patients remains unsatisfied. For further improving the prognosis evaluation system, we investigated the transcripts levels of PDCD7, FIS1, FAM3A, CA6, APP, KLRF1, ATCAY, GGT5 and Ang2 in 97 AML patients and 30 non-malignant controls, and validated using the published microarray data from 225 cytogenetically normal AML (CN-AML) patients treated according to the German AMLCG-1999 protocol. Real-time quantitative polymerase chain reaction and western blot were carried out, and clinical data were collected and analyzed. High Ang2 and FIS1 expression discriminated the CR rate of AML patients (62.5% versus 82.9% for Ang2, P = 0.011; 61.4% versus 82.2% for FIS1, P = 0.029). In CN-AML, patients with high FIS1 expression were more likely to be resistant to two courses of induction (P = 0.035). Overall survival (OS) and relapse-free survival (RFS) were shorter in CN-AML patients with high PDCD7 expression (P<0.001; P = 0.006), and PDCD7 was revealed to be an independent risk factor for OS in CN-AML (P = 0.004). In the analysis of published data from 225 CN-AML patients, PDCD7 remained independently predicting OS in CN-AML (P = 0.039). As a conclusion, Ang2 and FIS1 seem related to decreased CR rate of AML patients, and PDCD7 is associated with shorter OS and RFS in CN-AML. Hence, PDCD7, Ang2 and FIS1 may indicate a more aggressive form and poor prognosis of AML.
In this manuscript, an in situ layered intumescent flame retardant (IFR) of graphene oxide (GO) was used to produce a polybutylene terephthalate (PBT) flame‐retardant material with different flame‐retardant concentration gradients. IFR was introduced into the GO layered structure via a chemical reaction to achieve an in situ flame‐retardant effect. The elements of the composite were characterized using energy dispersive spectroscopy. The results showed that although the subsequent PBT‐based flame‐retardant composites displayed low flame‐retardant content, it exhibited excellent flame retardancy and mechanical properties. Due to the introduction of GO, the flame retardancy of the composites was improved significantly. The lamellar structure of GO provided a barrier allowing it to absorb condensed nucleus compounds. Therefore, continuous and compact scaly carbon layers were formed in the matrix during the burning process.
Three-dimensional (3D) covalent organic frameworks (COFs) are crystalline porous polymers with potential in numerous high-tech applications, but the linkages involved in their synthesis are still rather limited. Herein, we report novel 3D sp 2 carbon-linked COFs fabricated by the formation reaction of C=C bonds and their application in fluorescence imaging. These new COFs, namely JUC-580 and JUC-581, show high stability and excellent light-emitting properties in solid state and dispersed in various solvents. Furthermore, we investigate the potential application of JUC-581 as a drug carrier combined with fluorescence imaging. These results indicate that 3D sp 2 carbon-linked COFs are not only potential drug-loaded and sustained release materials but also promising cell fluorescent stains. This study thus expands the structural categories of 3D COFs based on different linkages, and promotes their prospective applications for biomedicine and fluorescent materials.
Using water as the sole solvent, the bifunctional molecule tetrakis(methylthio)-1,4-benzenedicarboxylic acid (TMBD) was reacted with Cu(CHCN)BF to form a robust microporous metal-organic framework (MOF, CityU-7) featuring Cu(I) ions being simultaneously bonded to the carboxyl and thioether donors. The MOF solid is stable in air and can be easily activated by heating, without the need for treatment with organic solvents. The subnanoscopic pores (ca. 0.6 nm) of the host net allow for uptake of CO and HO but exhibit lesser sorption for N at 77 K. The microporous net can also be penetrated by I molecules.
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