The specific spatial distribution of tissue generates a heterogeneous micromechanical environment that provides ideal conditions for diverse functions such as regeneration and angiogenesis. However, to manufacture microscale multicellular heterogeneous tissue modules in vitro and then assemble them into specific functional units is still a challenging task. In this study, a novel method for the digital assembly of heterogeneous microtissue modules is proposed. This technique utilizes the flexibility of digital micromirror device-based optical projection lithography and the manipulability of bubble-based microrobots in a liquid environment. The results indicate that multicellular microstructures can be fabricated by increasing the inlets of the microfluidic chip. Upon altering the exposure time, the Young’s modulus of the entire module and different regions of each module can be fine-tuned to mimic normal tissue. The surface morphology, mechanical properties, and internal structure of the constructed bionic peritoneum were similar to those of the real peritoneum. Overall, this work demonstrates the potential of this system to produce and control the posture of modules and simulate peritoneal metastasis using reconfigurable manipulation.
The purpose of this study was to investigate gender differences in quality of life and coping patterns after discharge for patients with burns in China. Cross-sectional survey research design and purposive sampling were used in this study, for which 92 subjects, including 56 males and 36 females, were recruited from a medical centre in central China. Quality of life was measured by the burn-specific health scale-brief (BSHS-B) and coping patterns were measured with the coping with burns questionnaire (CBQ), while demographic data was collected using a demographic questionnaire. An independent t-test and bivariate correlate were employed to analyse the data. The study results showed significant differences in quality of life between genders and coping patterns. There was a statistically significant gender difference in the sub-domain of the BSHS-B score for affect and relations, p < 0.05, and for coping patterns: emotion support, p < 0.05. The findings indicated that optimism/problem solving, revolution/ adjustment and avoidance were the most commonly used coping patterns for males and females. The rank orders were same. The study indicated that women are more sensitive to relationships with family after discharge and tend to exhibit depressive symptoms. For women, emotional support is more important than it is for men. A number of significant positive and negative correlations were found among the variables.
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