, a 70-year-old man presented with persistent vertigo and vomiting for 1 week, and intractable hiccups of about 3 years' duration. The frequency of hiccups was about 15-20 per minute, and it was not affected by eating and drinking. His hiccupping was persistent during the day, and it had not responded to metoclopramide, domperidone, omeprazole, or even traditional Chinese medicine. However, it stopped spontaneously while he was asleep. The physical and general medical examinations were normal, as was B-mode ultrasound of the abdomen and radiograph of the chest. Computed tomography of the head showed a single hyperintense spaceoccupying lesion (approximately 6.2 Â 6.3 cm 2) in the right frontotemporal lobe but mostly located in the frontal lobe, which was referred to as meningioma. Further contrast-enhanced scanning of the lesion showed that its signal intensity was obviously enhanced. A hypointense edema zone was found around the space-occupying lesion. Moreover, the right ventricle and left ventricle anterior horn became narrow, and the midline deviated about 1.5 cm to the left side (Figure). The space-occupying lesion was resected, and histologic examination confirmed the diagnosis of fibroblastic meningioma, World Health Organization grade I. Furthermore, the intractable hiccupping disappeared right after the operation without any antihiccup treatment drugs. As of now, no recurrences of persistent hiccups have been reported.
Colorectal cancer (CRC) is one of the common malignant tumors of digestive system, which the incidence of CRC has been on the rise in recent years. Omentin-1 is reported to be increased in plasma of CRC patients. The present study aimed to investigate whether Omentin-1 could promote the proliferation, invasion, migration and angiogenesis of colorectal cancer cells. ELISA assay and western blot analysis detected the Omentin-1 level in plasma of CRC patients and western blot analysis and RT-qPCR analysis detected the Omentin-1 level in colorectal cancer cell lines. The transfection effects were verified by western blot analysis. The cell proliferation, invasion and migration were determined by CCK-8 assay, wound healing assay and transwell assay. The expression of MMP2, MMP9, VEGF and AngII was analyzed by western blot analysis. The results showed that Omentin-1 was increased in plasma of CRC patients and colorectal cancer cell lines. Omentin-1 overexpression promoted the proliferation, invasion, migration and angiogenesis of colorectal cancer cells. And, up-regulation of Omentin-1 increased the expression of MMP2, MMP9, VEGF and AngII. In conclusion, our data suggested that Omentin-1 promoted the proliferation, invasion, migration and angiogenesis of colorectal cancer cells.
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