Palladium-catalyzed intermolecular amination of unactivated C(sp)-H bonds was developed. Using NFSI as both the amino source and the oxidant, this protocol operates under mild conditions with excellent terminal selectivity and a broad substrate scope. Moreover, the directing group can be easily removed to produce 1,2-amino alcohols.
Here described a copper-catalyzed direct chlorination and bromination of anilides in the presence of N-fluorobenzenesulfonimide as oxidant. This protocol shows excellent regioselec-tivity and mono-substitution with inexpensive KCl or NaBr as the halogen source and industrially friendly solvent.
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