We investigated the secondary metabolites present in
Penicillium janthinellum
MPT-25, an endophytic fungus
isolated from
Taxus wallichiana
var.
chinensis
(Pilger) Florin. Chemical characterization of
the solid cultured extract resulted in the isolation of 11 compounds,
including eight previously undescribed metabolites: a thiazolo[5,4-
b
]pyridine alkaloid, janthinedine A (
1
), and
seven
ar
-bisabol sesquiterpenes, janthinepenes A–G
(
2–8
). Their structures were elucidated by a combination
of extensive spectroscopic methods, including single-crystal X-ray
diffraction and ECD spectra. The antimicrobial activities of these
compounds were evaluated against seven agricultural pathogenic fungi
and eight clinically drug-resistant bacteria.
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