Technical advancements significantly improve earlier diagnosis of cervical cancer, but accurate diagnosis is still difficult due to various factors. We develop an artificial intelligence assistive diagnostic solution, AIATBS, to improve cervical liquid-based thin-layer cell smear diagnosis according to clinical TBS criteria. We train AIATBS with >81,000 retrospective samples. It integrates YOLOv3 for target detection, Xception and Patch-based models to boost target classification, and U-net for nucleus segmentation. We integrate XGBoost and a logical decision tree with these models to optimize the parameters given by the learning process, and we develop a complete cervical liquid-based cytology smear TBS diagnostic system which also includes a quality control solution. We validate the optimized system with >34,000 multicenter prospective samples and achieve better sensitivity compared to senior cytologists, yet retain high specificity while achieving a speed of <180s/slide. Our system is adaptive to sample preparation using different standards, staining protocols and scanners.

Transit offers stop-to-stop services rather than door-to-door services. The trip from a transit hub to the final destination is often entitled as the “last-mile” trip. This study innovatively proposes a hybrid approach by combining the data mining technique and multiple attribute decision making to identify the optimal travel mode for last-mile, in which the data mining technique is applied in order to objectively determine the weights. Four last-mile travel modes, including walking, bike-sharing, community bus, and on-demand ride-sharing service, are ranked based upon three evaluation criteria: travel time, monetary cost, and environmental performance. The selection of last-mile trip modes in Chengdu, China, is taken as a typical case example, to demonstrate the application of the proposed approach. Results show that the optimal travel mode highly varies by the distance of the “last-mile” and that bike-sharing serves as the optimal travel mode if the last-mile distance is no more than 3 km, whilst the community bus becomes the optimal mode if the distance equals 4 and 5 km. It is expected that this study offers an evidence-based approach to help select the reasonable last-mile travel mode and provides insights into developing a sustainable urban transport system.

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