Platelet-derived growth factor AA (PDGF-AA) is an important promoter of tissue injury repair and might be a candidate for improving the mechanical properties of repaired tendons. Here, we designed a PDGF-AA-modified poly(lactide-co-glycolide) acid (PLGA) electrospun fibers to promote tendon rehabilitation after injury. In the present study, we grafted PDGF-AA on the surface of PLGA. In structural experiments, we found that the hydrophilicity of PLGA containing PDGF-AA (PLGA-PDGF-AA) increased, but the strength of the material did not change significantly. Moreover, no significant changes in tendon cell proliferation and viability were observed in the PLGA-PDGF-AA treatment compared with the control group. The mouse tendon injury model ( n = 9) experiment illustrated that PLGA-PDGF-AA effectively promoted tendon healing, and we confirmed that PLGA-PDGF-AA promoted collagen synthesis and deposition by immunohistochemistry and RT-PCR. Moreover, the mechanical strength of PLGA-PDGF-AA-treated mouse ( n = 9) tendon tissue was also higher than that of the PLGA-treated group alone. In conclusion, PLGA-PDGF-AA promoted regeneration after tendon injury and serves as a potential adjuvant material for surgical tendon injury repair.
Dear Editor, We have read the article entitled "Risk factors for radiological hip involvement in patients with ankylosing spondylitis" that analyzes the risk factors of hip involvement in patients with ankylosing spondylitis (AS). In this study, the authors analyzed the clinical characteristics of patients with hip involvement due to AS evaluated by X-ray. From this analysis, it is found that juvenile onset, lower body mass index, and bone mass below the expected range for age were independently associated with radiological hip joint involvement in patients with AS and suggested that the use of nonsteroidal anti-inflammatory drugs can improve the prognosis 1 .However, from our point of view, some information need to be clear in this study.First, although the grading method of BASRI-hip based on X-ray examination has good reliability, it is not ideal in describing the sensitivity of severe hip involvement 2,3 . We still hope to read the data of morphological and histological changes of hip joint for quantitative evaluation.Second, in the study design, the inclusion criteria should be included in the latest diagnostic criteria 4 . It is particularly important to identify patients with negative radiological examination and to exclude all hip joint involvements not due to AS, such as hip joint injury caused by trauma, congenital disease, or systemic disease.Third, the clinical data of this study need to include the treatment factors affecting the hip involvement in the follow-up, such as whether the patient has undergone surgery, physical therapy, or rehabilitation treatment and the work, living environment, and lifestyle of patients 5 .
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.