The first example of diastereo- and enantioselective aza-MBH-type reaction was accomplished by the asymmetric synthesis of beta-nitro-gamma-enamines via a (1R,2R)-diaminocyclohexane thiourea derivative mediated tandem Michael addition and aza-Henry reaction in good yields (up to 95%) and high enantioselectivities (up to 91% ee) and diastereoselectivities (up to 1:99 dr).
A palladium‐catalyzed ortho‐directed alkylation of O‐methyl ketoximes that proceeds through a regioselective ring ‐opening reaction of epoxides has been demonstrated. This C(sp2)–H activation/alkylation protocol was carried out in pivalic acid/1,1,1,3,3,3‐hexafluoro‐2‐propanol (PivOH/HFIP, 2:8) as the solvent and was applied to various O‐methyl ketoximes that contain either electron‐donating or electron‐withdrawing groups. Moreover, different types of epoxides were used in this alkylation reaction, which proceeded smoothly to give the corresponding products in moderate to good yields.
An efficientl and enviromental friendly CuBr /NHPI co-catalyzed aerobic oxidative [3+2] cycloaddition-aromatization cascade was realized with N-substituted tetrahydroisoquinolines and electron-deficient olefins. Under the mild conditions, the reaction proceeded smoothly and...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.