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Long noncoding RNAs have an essential role in the tumorigenesis of breast cancer (BC). Nonetheless, the consequences of long intergenic noncoding RNA 00641 (LINC00641) in BC remain unidentified. This study shows that LINC00641 expression level was decreased in BC tissues. LINC00641 expression level was negatively related to tumor size, lymphnode metastasis, as well as clinical stage. LINC00641 overexpression inhibited cell proliferation, migration, and invasion but stimulated apoptosis in BC cells. LINC00641 overexpression also remarkably reduced BC growth and metastasis in vivo. LINC00641 acts as a competitive endogenous RNA to sponge miR-194-5p. miR-194-5p level was higher in BC tissues and cells compared with normal-adjacent tissues and normal breast epithelial cell. miR-194-5p expression was negatively correlated with LINC00641 expression in BC tissues. miR-194-5p overexpression reversed the effects of LINC00641 on cell proliferation, cycle, apoptosis, migration, as well as invasion. In conclusion, LINC00641 inhibits BC cell proliferation, migration, as well as invasion by sponging miR-194-5p. K E Y W O R D S breast cancer, LINC00641, lncRNA, metastasis, proliferation

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In order to control and remediate arsenic (As) contaminated soil, sediment or water, fungi are used to investigate their potential accumulation and volatilization of As. In this study, after cultivation for 2 days, the dry weights of mycelia for Trichoderma asperellum, Fusarium oxysporum and Penicillium janthinellum all show an increased trend when the As(V) concentration ranges from 0 -50, 0 -50, 0 -80 mg/L, respectively. When the culture system is loaded with 2500 lg As(V), which represents 50 mg/L As, and cultivated for 5 days, P. janthinellum presents the highest efficiency of 87.0 lg/g for As bioaccumulation, and the order of the efficiency for As bioaccumulation is P. janthinellum A T. asperellum A F. oxysporum. However, the order of the amount of volatilized As is F. oxysporum A P. janthinellum A T. asperellum, and the highest amount of volatilized As is observed for F. oxysporum at 181.0 lg. Thus, the ability of As bioaccumulation and biovolatilization for T. asperellum and P. janthinellum is reported for the first time in this study.

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