This is a repository copy of Identification of nonlinear time-varying systems using an online sliding-window and common model structure selection (CMSS)
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TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. Index terms-Time-varying common structure (TVCS) model, CMSS algorithm, recursive least squares (RLS) algorithm, nonlinear time-varying system identification, parameter estimation, online sliding window, EEG.-3 -
Metabolic interventions via targeting intratumoral dysregulated metabolism pathways have shown promise in reinvigorating antitumor immunity. However, approved small molecule immunomodulators often suffer from ineffective response rates and severe off‐target toxicity. ATP occupies a crucial role in energy metabolism of components that form the tumor microenvironment (TME) and influences cancer immunosurveillance. Here, a nanocarrier‐assisted immunometabolic therapy strategy that targets the ATP‐adenosine axis for metabolic reprogramming of TME is reported. An ecto‐enzyme (CD39) antagonist POM1 and AMP‐activated protein kinase (AMPK) agonist metformin are both encapsulated into cancer cell‐derived exosomes and used as nanocarriers for tumor targeting delivery. This method increases the level of pro‐inflammatory extracellular ATP (eATP) while preventing the accumulation of immunosuppressive adenosine and alleviating hypoxia. Elevated eATP triggers the activation of P2X7‐NLRP3‐inflammasome to drive macrophage pyroptosis, potentiates the maturation and antigen capacity of dendritic cells (DCs) to enhance the cytotoxic function of T cells and natural killer (NK) cells. As a result, synergistic antitumor immune responses are initiated to suppress tumor progress, inhibit tumor distant metastases, provide long‐term immune memory that offers protection against tumor recurrence and overcome anti‐PD1 resistance. Overall, this study provides an innovative strategy to advance eATP‐driven antitumor immunity in cancer therapy.
The purpose of this paper is to propose an algorithm for solvingthe split common fixed point problems for total asymptotically strictly pseudocontractive mappingsin infinite-dimensional Hilbert spaces. The results presented in the paper improve and extend some recent results of Moudafi (2011 and 2010), Xu (2010 and 2006), Censor and Segal (2009), Censor et al. (2005), Masad and Reich (2007), Censor et al. (2007), Yang (2004), and others.
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