Nummular headache (NH) is defined as a focal head pain that is exclusively felt in a small area, which is typically 1-6 cm in diameter. Neurological examinations are normal in all patients, but this report describes a new variant. A patient was identified who presented with focal head pain that was approximately 8 cm in diameter and bitrigeminal hyperalgesia on neurological examination. Treatment with carbamazepine provided significant analgesic relief in terms of both the frequency and intensity of pain. The findings enlarge the clinical diversity of this headache disorder. The pathogenic mechanisms of NH may be similar to trigeminal neuralgia in particular patients.
AJC-15032Osteogenesis relates to biomineralization of CaCO3 deposition doped with multiple amino acids. The crystallization of CaCO3 in the presence of methionine with extremely unusual, ginger-shaped morphology is reported in this article. We show that unusual gingershaped CaCO3 vaterite crystals selectively grow from the edge of rhombohedral calcite crystals with certain degree of preferred orientation. The unusual morphology and the growth process of the ginger-shaped vaterite CaCO3 crystals were discussed with emphasis on methionine mediated selective binding and oriented aggregation/attachment of vaterite nanocrystals. Moreover, crystallization of CaCO3 in the presence of methionine, a classified nonpolar amino acid, revealed atypical polymorphic selectivity, where vaterite is the major component. With all these in regards, this study further confirmed that nature of amino acid is crucial in achieving the desired selectivity in polymorph nucleation, as well controlling the crystalline nature and morphology of the CaCO3 crystals.
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